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Histamine release and hepatic elimination of histamine following abdominal surgery

Histaminfreisetzung und Leberfunktion

  • 1. Adverse Reactions And Histamine Release In Anaesthesia And Surgery
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Summary

Histamine concentration in the systemic and splanchnic blood increases after major surgical trauma for a period of 3–5 days. The intestinal organs release a larger quantity of histamine into the portal blood during the first postoperative days. The human liver in a healthy state eliminates histamine from the portal vein blood in the range of 45–60%.

Histamine elimination by the cirrhotic liver seems to be decreased.

Zusammenfassung

Nach Bauchoperationen steigt die Histamin-Konzentration in der Pfortader und den peripheren Venen für 3–5 Tage deutlich an. Aus dem gastrointestinalen Gewebe wird in der frühen postoperativen Periode Histamin in größerer Menge in das Pfortaderblut freigesetzt. Beim Menschen eliminiert die gesunde Leber 45–60% des Histamins aus dem Pfortaderblut.

Die Histaminextraktion der zirrhotischen Leber erscheint vermindert zu sein.

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Authors and Affiliations

  1. Department of Surgery, University of Ulm, Steinhövelstr. 7, D-7900, Ulm, Federal Republic of Germany

    H. G. Beger

  2. Department of Gastroenterology, Klinikum Charlottenburg, Free University of Berlin, Spandauer Damm 130, D-1000, Berlin 19

    D. Stopik

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  1. H. G. Beger
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  2. D. Stopik
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Beger, H.G., Stopik, D. Histamine release and hepatic elimination of histamine following abdominal surgery. Klin Wochenschr 60, 935–938 (1982). https://doi.org/10.1007/BF01716950

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  • DOI: https://doi.org/10.1007/BF01716950

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