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Einbau von C14- und H3-Tryptophan in verschiedene Serumproteine durch die isolierte perfundierte normale und bestrahlte Leber

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Zusammenfassung

Der Einbau von3H benzolmarkiertem und14C alaninmarkiertem Tryptophan in verschiedene Serumproteine wurde in der isolierten perfundierten Leber untersucht. Nach Ganzkörperbestrahlung (24 Std nach 1000 R) nimmt der Einbau von3H-Tryptophan zu, dagegen wird weniger14C eingebaut, da durch verminderten Abbau von Tryptophan, weniger14C-Alanine und seine Metabolite zur Verfügung stehen.

Summary

The incorporation of3H-benzene and14C alanyl labeled tryptophan into different serum proteins was investigated in the isolated perfused liver. Total body X-irradiation (24 hours after 1000 R) results in an increase in incorporation of3H tryptophan and in a decrease of incorporation of14C label. It is suggested, that less alanine and its metabolites are available after irradiation due to a diminished catabolism of tryptophan.

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Literatur

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Authors and Affiliations

  1. C.E.N. and Euratom Dept. Radiobiologie MOL, Belgien

    A. M. Reuter, G. B. Gerber, K. J. Altman, G. Deknudt & F. Kennes

Authors
  1. A. M. Reuter
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  2. G. B. Gerber
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  3. K. J. Altman
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  4. G. Deknudt
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  5. F. Kennes
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Reuter, A.M., Gerber, G.B., Altman, K.J. et al. Einbau von C14- und H3-Tryptophan in verschiedene Serumproteine durch die isolierte perfundierte normale und bestrahlte Leber. Klin Wochenschr 44, 1310–1312 (1966). https://doi.org/10.1007/BF01716604

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  • DOI: https://doi.org/10.1007/BF01716604

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