References
Steere, A. C. Lyme disease. N Engl J Med, 321 (1989) 586–596.
Schaible, U. E., Kramer, M. D., Museteanu, C., Zimmer, G., Mossmann, H., Simon, M. M. The severe combined immunodeficiency (scid) mouse: A laboratory model for the analysis of Lyme arthritis. J. Exp Med 170 (1989) 1427–1432.
Schaible, U. E., Gay, S., Museteanu, C., Kramer, M. D., Zimmer, G., Eichmann, K., Museteanu, U., Simon, M. M. Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver. Am. J. Pathol. 137 (1990) 811–820.
Museteanu, C., Schaible, U. E., Stehle, T., Kramer, M. D., Simon, M. M. Myositis in mice inoculated withBorrelia burgdorferi. Am. J. Pathol. 139 (1991) 1267–1271.
Schaible, U. E., Kramer, M. D., Justus, C. W. E., Museteanu, C., Simon, M. M. Demonstration of antigen-specific T cells and histopathological alterations in mice experimentally inoculated withB. burgdorferi. Infect. Immun. 57 (1989) 41–47.
Schaible, U. E., Kramer, M. D., Eichmann, K., Modolell, M., Museteanu, C., Simon, M. M. Monoclonal antibodies specific for the outer surface protein A (OspA) ofBorrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc. Natl. Acad. Sci. USA 87 (1990) 3768–3772.
Schaible, U. E., Wallich, R., Kramer, M. D., Museteanu, C., Rittig, M., Moter, S., Simon, M. M.: Role of the immune response in Lyme disease: Lessons from a mouse model. In: Schutzer, S. E. (ed.): Lyme disease. Molecular and immunologic approaches. Cold Spring Harbour Laboratory Press 1992, pp. 243–262.
Simon, M. M., Schaible, U. E., Wallich, R., Kramer, M. D. A mouse model forBorrelia burgdorferi infection: approach to a possible vaccine against Lyme disease. Immunol Today 12 (1991) 11–16.
Simon, M. M., Altenschmidt, U., Böggemeyer, E., Gern, L., Fuchs, H., Honarvar, N., Hurtenbach, U., Kurtenbach, K., Modolell, M., Moter, S., Museteanu, C., Schaible, U. E., Wallich, R., Kramer, M. D. Pathogenesis of Lyme borreliosis: lessons from the mouse model. In:Cevenini, R., Sambri, V., La Placa, M. (eds.): Advances in Lyme borreliosis research. Proceedings of the VI International Conference on Lyme Borreliosis. Societa Editrice Esculapio, Bologna 1994, pp. 69–75.
Simon, M. M., Schaible, U. E., Kramer, M. D., Eckerskorn, C., Museteanu, C., Müller-Hermelink, H. K., Wallich, R. Recombinant outer surface protein A fromBorrelia burgdorferi induces protective antibodies against spirochetal infection in mice. J. Infect. Dis. 164 (1991) 123–132.
Wallich, R., Schaible, U. E., Simon, M. M., Heiberger, A., Kramer, M. D. Cloning and sequencing of the gene encoding the outer surface protein A (OspA) of an europeanBorrelia burgdorferi isolate. Nucleic Acids Res. 21 (1989) 8864.
Kramer, M. D., Wallich, R., Simon, M. M. The outer surface protein A (OspA) ofBorrelia burgdorferi: a vaccine candidate and bioactive mediator. Infection 24 (1996) 190–194.
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Wallich, R., Kramer, M.D. & Simon, M.M. The recombinant outer surface protein A (lipOspA) ofBorrelia burgdorferi: A lyme disease vaccine. Infection 24, 396–397 (1996). https://doi.org/10.1007/BF01716093
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DOI: https://doi.org/10.1007/BF01716093