Summary
In 15 consecutive subjects hospitalized with nephropathia epidemica, a European form of hemorrhagic fever with renal syndrome, the plasma concentrations of nitrate plus nitrite, stable metabolites of nitric oxide, were determined. From day 3 of onset of disease the concentrations increased, peak levels being reached on days 5 to 7. Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r=−0.64, p=0.02) and levels of tumor necrosis factor (TNF)-α (r=0.51, p=0.05) and soluble TNF receptors p55 and p75 (r=0.58, p=0.03 and r=0.54, p=0.04, respectively) but not to levels of interferon-γ or interleukin-10 (p>0.05). The results are compatible with the well-known capacity of TNF-α to enhance production of nitric oxide, and suggest that nitric oxide may be of physiologic importance in hemorrhagic fever with renal syndrome.
Zusammenfassung
Bei 15 aufeinanderfolgenden, stationär eingewiesenen Patienten mit Nephropathia epidemica, einer europäischen Form des hämorragischen Fiebers mit renalen Syndrom, wurden die Plasmakonzentrationen von Nitrat plus Nitrit, den stabilen Metaboliten von Stickoxid, gemessen. Von dem dritten Tag nach Ausbruch der Krankheit an begannen die Konzentrationen anzusteigen. Höchstwerte wurden am Tag 5–7 beobachtet. Maximale Plasmakonzentrationen von Nitrat plus Nitrit waren mit dem Grad der Hypotension korreliert (r = −0.64, p = 0.02) und auch mit der Konzentration Tumor-Nekrose-Faktor (TNF)-α (r = 0.51, p = 0.05) und löslichen TNF Rezeptoren p55 und p75 (r = 0.58, p = 0.03 und r = 0.54, p = 0.04), aber nicht mit den Interferon-γ oder Interleukin-10 Werten (p>0.05). Die TNF-α-abhängige Produktion von Stickoxiden könnte von pathophysiologischer Bedeutung bei Nephropathia epidemica sein.
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Linderholm, M., Tärnvik, A. & Groeneveld, P.H.P. Increased production of nitric oxide in patients with hemorrhagic fever with renal syndrome — Relation to arterial hypotension and tumor necrosis factor. Infection 24, 337–340 (1996). https://doi.org/10.1007/BF01716075
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DOI: https://doi.org/10.1007/BF01716075