Klinische Wochenschrift

, Volume 65, Issue 5, pp 225–231 | Cite as

Neopterin im Serum und Urin zur Differentialdiagnose von Nierenfunktionsstörungen nach Nierentransplantation

  • J. Wolf
  • E. Musch
  • H. Neuss
  • U. Klehr
Originalien

Abkürzungen

CyA

Cyclosporin A

Kr-Cl

Kreatinin-Clearance

NPT-Cl

Neopterin-Clearance

sKr

Kreatinin im Serum

sNPT

Neopterin im Serum

uNPT

Neopterin im Urin

Neopterin in serum and urine for the differential diagnosis of renal dysfunction in kidney allograft recipients

Summary

In a period of 10 months neopterin in serum and urine was determined by radioimmunoassay in 33 renal allograft recipients treated with cyclosporin A. While in allograft rejections the highest neopterin concentrations were found in the serum, patients with viral infections after renal transplantation showed the most elevated concentrations in the urine. For early diagnosis of allograft rejection the ratio of neopterin clearance and serum-neopterin was the most significant criterion of the parameters measured in this study. Patients without complications during the follow-up showed slightly elevated and stable neopterin levels in serum and urine. The presented results indicate that neopterin is a useful parameter for the follow-up after renal allograft transplantation and for the diagnosis of immunological complications.

Key words

Neopterin Renal transplantation Allograft rejection Infection Cyclosporin A 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • J. Wolf
    • 1
  • E. Musch
    • 1
  • H. Neuss
    • 1
  • U. Klehr
    • 1
  1. 1.Medizinische Universitätsklinik Bonn-VenusbergGermany

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