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Renal metabolism of corticosteroid hormones

Renaler Corticosteroid Stoffwechsel

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Summary

IK and STF from male and female rats have been used to study in vitro the renal metabolism of B. in male rat tissue four lipid soluble metabolites (I–IV) have been found, I+II being more polar and III+IV being less polar than B. I and II have been identified as 11-dehydro-20-hydroxy-B and 20-hydroxy-B. The structure of III and IV remains to be determined. Renal tissue from female rats produced predominantly III indicating sexual variations of steroid metabolism in kidneys. — The literature has been reviewed which documents that the kidneys in addition to B metabolize A, cortisol, progesterone and other corticosteroids.

Zusammenfassung

In IK und STF von männlichen und weiblichen Ratten wurde der renale Stoffwechsel von B in vitro untersucht. Bei männlichen Ratten wurden vier lipidlösliche Metabolite (I–IV) gefunden. I und II waren polarer als B; die Strukturanalyse ergab für I: 11-dehydro-20-hydroxy-B und für II: 20-hydroxy-B. Die Struktur der beiden Metabolite III und IV, die weniger polar waren als B, konnte noch nicht aufgeklärt werden. Nierengewebe von weiblichen Ratten bildete aus B vorwiegend die weniger polaren Metabolite III und IV. Der renale Stoffwechsel von B ist somit geschlechtsabhängig. — Eine Übersicht über die Arbeiten in der Literatur belegt, daß die Nieren nicht nur B sondern auch A, Cortisol, Progesteron und andere CS metabolisieren.

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Abbreviations

A:

Aldosterone

B:

Corticosterone

Alb:

Albumin

CS:

Corticosteroids

MCS/GCS:

Mineralo-/gluco-CS

IK:

Isolated (perfused) kidney

STF:

Suspended tubular fragments

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Authors and Affiliations

  1. Dept. Klinische Physiologie, Klinikum Steglitz, Freie Universität Berlin, Germany

    K. Hierholzer, I. Lichtenstein, H. Siebe, D. Tsiakiras & I. Witt

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  1. K. Hierholzer
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  2. I. Lichtenstein
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  3. H. Siebe
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  4. D. Tsiakiras
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  5. I. Witt
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Supported by Deutsche Forschungsgemeinschaft Hi 97/16

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Hierholzer, K., Lichtenstein, I., Siebe, H. et al. Renal metabolism of corticosteroid hormones. Klin Wochenschr 60, 1127–1135 (1982). https://doi.org/10.1007/BF01715842

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