Infection

, Volume 19, Supplement 7, pp S388–S390 | Cite as

Double-blind comparative study of ofloxacin (hoe 280) and trimethoprim-sulfamethoxazole in the treatment of patients with acute exacerbations of chronic bronchitis and chronic obstructive lung disease

  • N. P. Boye
  • P. Gaustad
Article

Summary

In a double-blind study of 137 patients with exacerbation of chronic bronchitis and chronic obstructive lung disease, the efficacy and safety of ofloxacin was compared with that of trimethoprim-sulfamethoxazole (TMP/SMX). Both groups improved. The frequency of severe adverse reactions was highest in the TMP/SMX group, and 14.9% of the patients discontinued the treatment. In the ofloxacin group 6% had to stop the treatment. The failure rate was significantly lower in the ofloxacin-treated patients, 3.2% versus 13.8% in the TMP/SMX group. Ofloxacin was found to be an effective drug with few adverse reactions.

Keywords

Lung Disease Adverse Reaction Failure Rate Bronchitis Ofloxacin 

Doppelblindstudie zum Vergleich von Ofloxacin (Hoe 280) und Trimethoprim-Sulfamethoxazol bei Patienten mit akuter Exazerbation einer chronischen Bronchitis bei chronisch obstruktiver Lungenerkrankung

Zusammenfassung

Im Rahmen einer Doppelblindstudie wurden Ofloxacin und Trimethoprim-Sulfamethoxazol (TMP/SMX) bezüglich ihrer Wirksamkeit und Sicherheit bei 137 Patienten mit Exazerbation einer chronischen Bronchitis bei chronisch obstruktiver Lungenerkrankung verglichen. Schwere Arzneimittelnebenwirkungen waren in der TMP/SMX-Gruppe häufiger und führten in 14,9% der Fälle zur vorzeitigen Beendigung der Therapie, in der Ofloxacingruppe nur in 6% der Fälle. Bei Patienten, die mit Ofloxacin behandelt wurden, war die Versagerquote signifikant geringer als bei Behandlung mit TMP/SMX (3,2 im Vergleich zu 13,8%). Ofloxacin erwies sich als wirksames Arzneimittel und verursachte nur wenige unerwünschte Nebenwirkungen.

References

  1. 1.
    Lamberts, H. P., Stern, H. Infective factors in exacerbations of bronchitis and asthma. Brit. Med. J. 3 (1972) 323–327.Google Scholar
  2. 2.
    Nicotra, M. B., Rivera, M. Awe, R. J. Antibiotic therapy in acute exacerbations of chronic bronchitis: a controlled study using tetracycline. Ann. Intern. Med 97 (1982) 18–21.Google Scholar
  3. 3.
    Anthonsien, N. R., Manfreda, J., Warren, C. P. W., Hersfield, E. S., Harding, G. K. M., Nelson, N. A. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann. Intern. Med. 106 (1987) 196–204.Google Scholar
  4. 4.
    Egede, F., Kristensen, I. A clinical comparative study of ofloxacin and pivampicillin in acute exacerbations of chronic bronchitis. J. Antimicrob. Chemother. 22 (1988) (Suppl. C) 139–142.Google Scholar
  5. 5.
    Malone, D. N., Gould, J. C., Grant, I. W. B. A comparative study of ampicillin, tetracycline hydrochloride, and methacycline hydrochloride in acute exacerbations of chronic bronchitis. Lancet ii (1968) 594–596.Google Scholar
  6. 6.
    Perea, E. J. Ofloxacin concentrations in tissues involved in respiratory tract infections. J. Antimicrob. Chemother. 26 (1990) (Suppl. D) 55–60.Google Scholar
  7. 7.
    Hooper, J. A., Wolfson, J. S. Fluoroquinolone antimicrobial agents. N. Engl. J. Med. 324 (1991) 384–394.Google Scholar
  8. 8.
    Johnston, R. N., McNeill, R. S., Smith, D. H., Dempster, M. B., Nairn, J. R., Purvis, M. S., Watsdon, J. M., Ward, F. G. Five-year winter chemoprophylaxis for chronic bronchitis. Brit. Med. J. 4 (1969) 265–269.Google Scholar
  9. 9.
    Moorhouse, E. C., Clarke, P. C. Efficacy of ofloxacin in the treatment of lower respiratory infections in general practice. J. Antimicrob. Chemother. 22 (1988) (Suppl. C) 135–138.Google Scholar
  10. 10.
    Kobayashi, H. Clinical evaluation of ofloxacin in lower respiratory tract infections. Infection 14 (1986) (Suppl. 4) 279–282.Google Scholar
  11. 11.
    Ball, P. Overview of experience with ofloxacin in respiratory tract infection. Scand. J. Infect. Dis. (Suppl. 68) (1990) 56–63.Google Scholar

Copyright information

© MMV Medizin Verlag GmbH München 1991

Authors and Affiliations

  • N. P. Boye
    • 1
  • P. Gaustad
    • 2
  1. 1.Dept. of Lung DiseasesUllevaal University HospitalOslo 4Norway
  2. 2.Dept. of MicrobiologyUllevaal University HospitalOslo 4Norway

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