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Lack of elevation of β-thromboglobulin and platelet factor 4 in plasma during exercise in patients with chronic peripheral arterial occlusive disease

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Summary

We investigated the behavior of β-thromboglobulin (β-TG) and platelet factor 4 (PF 4) during exercise — upright bicycle ergometry — in 30 patients (median age, 62.4 years) with arteriographically proven peripheral arterial occlusive disease (PAOD) in a chronic stable phase. In 15 patients the exercise study was done twice; the second time was concurrent with administration of acetylsalicylic acid (ASA) in a dosage of 1.0 g/day, while the first time was without ASA therapy. There were no significant differences in either the group of patients with or that without ASA with regard to the platelet-specific proteins at rest, immediately after, and 30 min after exercise. Blood collected simultaneously (n=6) from an arm vein and from a femoral artery and femoral vein also revealed no significant differences. Our findings support the conclusion that exercise-induced peripheral ischemia with severe symptoms of claudication does not produce platelet alpha-granule release.

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Abbreviations

ASA:

acetylsalicylic acid

CV:

coefficient of variation

PAOD:

peripheral arterial occlusive disease

PF 4:

platelet factor 4

β-TG:

β-thromboglobulin

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Authors and Affiliations

  1. Abteilung für Angiologie, I. Medizinische Universitätsklinik, Wien

    E. Minar, H. Ehringer & R. Schöfl

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  1. E. Minar
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  2. H. Ehringer
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  3. R. Schöfl
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Minar, E., Ehringer, H. & Schöfl, R. Lack of elevation of β-thromboglobulin and platelet factor 4 in plasma during exercise in patients with chronic peripheral arterial occlusive disease. Klin Wochenschr 65, 419–423 (1987). https://doi.org/10.1007/BF01715764

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  • DOI: https://doi.org/10.1007/BF01715764

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