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Penetration of ciprofloxacin into the human pancreas

Penetration von Ciprofloxacin ins menschliche Pankreas

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Summary

The aim of this study was to determine the concentrations of ciprofloxacin in human pancreatic tissue and juice. Concentrations were measured by high-pressure liquid chromatography (HPLC). Two hundred mg of ciprofloxacin were administered as a short i. v. infusion (30 min). The median ciprofloxacin concentrations 140 min (median) after the start of infusion in pancreatic tissue as well as in pancreatic juice were 0.9 mg/kg (mg/l). The penetration ratio was 1.0 for pancreatic tissue and 0.83 for pancreatic juice. With regard to the minimal inhibitory concentrations (MIC) for the respective bacteria, ciprofloxacin seems to be an appropriate drug for the treatment of septic complications in necrotizing pancreatitis. Future clinical trials are necessary to prove this assumption.

Zusammenfassung

Ziel dieser Studie war es, die Konzentrationen von Ciprofloxacin im menschlichen Bauchspeicheldrüsengewebe und -saft zu ermitteln. Die von uns mittels Hochdruck-Flüssigkeitschromatographie (HPLC) ermittelte Konzentration betrug sowohl in menschlichem Pankreasgewebe wie auch im Pankreassaft im Median 0,9 mg/kg (mg/l) 140 min (Median) nach Beginn der intravenösen Kurzinfusion (30 min) von 200 mg Ciprofloxacin. Das Verhältnis der Gewebekonzentration zur zeitgleich vorhandenen Serumkonzentration betrug im Median für Pankreasgewebe 1,0 und für Pankreassaft 0,83. Im Vergleich mit den publizierten minimalen Hemmkonzentrationen für die relevanten Bakterien zeigt sich, daß Ciprofloxacin aufgrund seiner pharmakokinetischen Daten im Pankreas zur Behandlung septischer Komplikationen der akuten Pankreatitis geeignet erscheint. Allerdings sind weitere klinische Studien notwendig, um diese Vermutung zu beweisen.

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Authors and Affiliations

  1. Abteilung für Innere Medizin, Kreiskrankenhaus, Eybstraße 16, D-73312, Geislingen

    R. Isenmann &  K. Fleischer

  2. Mibicon GmbH, D-79117, Freiburg, Germany

    P. Schlegel

  3. Klinik für Viszerale und Transplantationschirurgie, Universitätsspital, Murtenstraße, CH-3010, Bern, Switzerland

    H. Frieß &  M. W. Büchler

Authors
  1. R. Isenmann
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  2. K. Fleischer
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  3. P. Schlegel
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  4. H. Frieß
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  5. M. W. Büchler
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Isenmann, R., Fleischer, K., Schlegel, P. et al. Penetration of ciprofloxacin into the human pancreas. Infection 22, 343–346 (1994). https://doi.org/10.1007/BF01715543

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