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Automating combinatorial chemistry: A primer on benchtop robotic systems

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Summary

Benchtop robotic systems are inexpensive, flexible automation tools with potential applications in a wide array of disciplines such as combinatorial chemistry, high-throughput screening, and genomics. We explain the basic components of a benchtop system and explore factors to consider when purchasing or customizing a robot, such as automation benefits, vendor selection, and current system limitations. Issues involving system specification, software design, and hardware customization are then discussed. Additionally, system optimization, validation, and support are detailed. Given a properly designed and implemented system, the combinatorial laboratory can markedly increase compound synthesis and purification.

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References

  1. Advanced ChemTech, 5609 Fern Valley Road, Louisville, KY 40228, U.S.A.

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Authors and Affiliations

  1. Lilly Research Laboratories, A Division of Eli Lilly & Co., Lilly Corporate Center, 46285, Indianapolis, IN, USA

    Jill H. Hardin & Frank R. Smietana

Authors
  1. Jill H. Hardin
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  2. Frank R. Smietana
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Hardin, J.H., Smietana, F.R. Automating combinatorial chemistry: A primer on benchtop robotic systems. Mol Divers 1, 270–274 (1996). https://doi.org/10.1007/BF01715532

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  • DOI: https://doi.org/10.1007/BF01715532

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