Annals of Hematology

, Volume 70, Issue 1, pp 47–51 | Cite as

Mantle cell lymphoma with the features of mucosa-associated lymphoid tissue (MALT) lymphoma in an HTLV-I-seropositive patient

  • K. Shibata
  • Y. Shimamoto
  • S. Nakano
  • M. Miyahara
  • H. Nakano
  • M. Yamaguchi
Case Report

Summary

A case of small lymphocytic B-cell lymphoma with seropositivity for human T-cell leukemia virus type I (HTLV-I), whose clinical features were closely related to those of mucosa-associated lymphoid tissue (MALT) lymphoma, is presented. The neoplastic cells of the lymph node were immunologically positive for CD5, in addition to several B-cell markers, but negative for CD10, and cytogenetically carried a t(11;14)(q13;q32). These findings were fully consistent with so-called mantle cell lymphoma (MCL). In addition to the lymph nodes and bone marrow, multiple extranodal sites including lacrimal and salivary glands, lung and stomach (where MALT is present) were occupied by lymphoma cells. These extranodal lesions were immunologically identical to the lymph nodes (CD5(+), CD10(−)), but histologically showed lymphoepithelial lesions (LEL) characteristic of MALT lymphoma. These findings suggest a possible relationship between MCL and MALT lymphoma, and the neoplastic cells are thought to originate from the CD5-positive B cells, which are present near the areas across the mantle and marginal zones. Furthermore, HTLV-I-infection, which appears to create an immunodeficient state or modulate the B-cell response, is thought to play a role in B-cell lymphomagenesis.

Key words

CD5 Human leukemia virus type I (HTLV-I) Mantle cell lymphoma (MCL) Mucosa-associated lymphoid tissue (MALT) t(11,14) 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Agnarsson BA, Kadin ME (1987) An unusual B-cell lymphoma simulating hairy cell leukemia. Am J Clin Pathol 88:752–759Google Scholar
  2. 2.
    Banks PM, Chan J, Cleary ML, Delsol G, De Wolf-Peeters D, Gatter K, Grogan TM, Harris NL, Isaacson PG, Jaffe ES, Mason D, Pileri S, Ralfkiaer E, Stein H, Warnke RA (1992) Mantle cell lymphoma: a proposal for unification of morphologic, immunologic, and molecular data. Am J Surg Pathol 16:637–640Google Scholar
  3. 3.
    Carbone A, Manconi R, Poletti A, Gloghini A, De Paoli P, Volpe R (1988) Expression of Leu-8 surface antigen in B-cell lymphomas. Correlation with other B-cell markers. J Pathol 154:133–140Google Scholar
  4. 4.
    Cleary ML, Sklar J (1984) Lymphoproliferative disorders in cardiac transplant recipients are multiclonal lymphomas. Lancet 1:489–493Google Scholar
  5. 5.
    Duggan MJ, Weisenburger DD, Ye YL, Bast MA, Pierson JL, Linder J, Armitage JO (1990) Mantle zone lymphoma: a clinicopathologic study of 22 cases. Cancer 66:522–529Google Scholar
  6. 6.
    Harris NL (1991) Extranodal lymphoid infiltrates and mucosa-associated lymphoid tissue (MALT): a unifying concept. Am J Surg Pathol 15:879–884Google Scholar
  7. 7.
    Harris NL, Bhan AK (1985) Mantle-zone lymphoma: a pattern produced by lymphomas of more than one cell type. Am J Surg Pathol 9:872–882Google Scholar
  8. 8.
    Ida H, Kurata A, Eguchi K, Kawakami A, Migita K, Fukuda T, Nakamura T, Kusumoto Y, Berzofsky JA, Nagataki S (1991) Different B-cell responses to human T-cell lymphotropic virus type I (HTLV-I) envelope synthetic peptides in HTLV-I-infected individuals. J Clin Immunol 11:143–151Google Scholar
  9. 9.
    Isaacson PG (1992) Extranodal lymphomas: the MALT concept. Verh Dtsch Ges Pathol 76:14–23Google Scholar
  10. 10.
    Isaacson P, Wright DH (1983) Malignant lymphoma of mucosa-associated lymphoid tissue: a distinctive type of B-cell lymphoma. Cancer 52:1410–1416Google Scholar
  11. 11.
    Lardelli P, Bookman MA, Sundeen J, Longo DL, Jaffe ES (1990) Lymphocytic lymphoma of intermediate differentiation: morphologic and immunophenotypic spectrum and clinical correlations. Am J Surg Pathol 14:752–763Google Scholar
  12. 12.
    Mann DL, DeSantis P, Mark G, Pfeifer A, Newman M, Gibbs N, Popovic M, Sarngadharan MG, Gallo RC, Clark J, Blattner W (1987) HTLV-I-associated B-cell CLL: indirect role for retrovirus in leukemogenesis. Science 236:1103–1106Google Scholar
  13. 13.
    Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A (1991) A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 350:512–515Google Scholar
  14. 14.
    Ono N (1991) Histologic and immunohistochemical study of primary gastrointestinal lymphoma. J Jap Soc RES 31:237–256Google Scholar
  15. 15.
    Raffeld M, Jaffe ES (1991) bcl-1, t(11;14), and mantle cell-derived lymphomas. Blood 78:259–263Google Scholar
  16. 16.
    Rivas C, Echezarreta G, Garcia R, Santos M, Santon A, Robledo M, Benitez J, Oliva H, Delsol G (1992) A multiparametric study of malignant lymphoma of mucosa, associated lymphoid tissue (Malt). Leukemia and Lymphoma 8:87–96Google Scholar
  17. 17.
    Robinson JE, Brown N, Andiman W, Halliday K, Francke U, Robert MF, Andersson-Anvret M, Horstmann D, Miller G (1980) Diffuse polyclonal B-cell lymphoma during primary infection with Epstein-Barr virus. N Engl J Med 302:1293–1297Google Scholar
  18. 18.
    Shearer WT, Ritz J, Finegold MJ, Guerra IC, Rosenblatt HM, Lewis DE, Pollack MS, Taber LH, Sumaya CV, Grumet FC, Cleary ML, Warnke R, Sklar J (1985) Epstein-Barr virus-associated B-cell proliferations of diverse clonal origins after bone marrow transplantation in a 12-year-old patient with severe combined immunodeficiency. N Engl J Med 312:1151–1159Google Scholar
  19. 19.
    Shimamoto Y, Suga K, Shibata K, Matsuzaki M, Yano H, Yamaguchi M (1994) Clinical importance of extraordinary integration patterns of human T-cell lymphotrophic virus type I proviral DNA in adult T-cell leukemia/lymphoma. Blood 84:853–858Google Scholar
  20. 20.
    Sundeen JT, Longo DL, Jaffe ES (1992) CD5 expression in B-cell small lymphocytic malignancies: correlation with clinical presentation and sites of disease. Am J Surg Pathol 16:130–137Google Scholar
  21. 21.
    Tobinai K, Ohtsu T, Hayashi M, Kinoshita T, Matsuno Y, Mukai K, Shimoyama M (1991) Epstein-Barr virus (EBV) genomic carrying monoclonal B-cell lymphoma in a patient with adult T-cell leukemia-lymphoma. Leuk Res 15:837–846Google Scholar
  22. 22.
    Verastegui E, Ortega V, Soler C, de la Vega SL, Ocadiz R, Meneses A, Reynoso E, Alfaro G (1992) Primary B-cell lymphoma of the rectum in a patient coinfected with HIV-1 and HTLV-I. Rev Inv Clin 44:387–392Google Scholar
  23. 23.
    Wotherspoon AC, Pan L, Diss TC, Isaacson PG (1992) Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue. Cancer Genet Cytogenet 58:35–38Google Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • K. Shibata
    • 1
  • Y. Shimamoto
    • 1
  • S. Nakano
    • 2
  • M. Miyahara
    • 1
  • H. Nakano
    • 1
  • M. Yamaguchi
    • 1
  1. 1.Division of Hematology, Department of Internal MedicineSaga Medical SchoolSagaJapan
  2. 2.Department of PathologySaga Medical SchoolSagaJapan

Personalised recommendations