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Sweet's syndrome as the presenting symptom of hairy cell leukemia with concomitant infection by Mycobacterium kansasii

Annals of Hematology volume 65, pages 55–58 (1992)Cite this article

Summary

A patient with Sweet's syndrome and leukopenia is reported. Hematological evaluation revealed hairy cell leukemia (HCL). The clinical picture was dominated by persistent fever, which is a common feature of both Sweet's syndrome and HCL. Since fever frequently reflects concomitant infection in HCL, a thorough search for infectious disease was performed. Blood cultures grewMycobacterium kansasii. The patient recovered after treatment with recombinant interferon-α (r-IFN-α) and tuberculostatic drugs. Remarkably, the skin lesions completely regressed within 1 week after the start of r-IFN-α. In the literature, Sweet's syndrome is rarely mentioned as a feature of HCL. Mycobacterial disease, especially atypical mycobacteria, is relatively often seen in HCL.

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Affiliations

  1. Department of Hematology, University Hospital Nijmegen, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands

    C. Kramers, J. M. M. Raemaekers & B. E. de Pauw

  2. Department of Dermatology, University Hospital Nijmegen, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands

    H. M. J. van Baar

  3. Department of Medical Microbiology, Bronovo Hospital, Bronovolaan 5, 2597, AX 's Gravenhage, The Netherlands

    A. M. Horrevorts

Authors
  1. C. Kramers
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  2. J. M. M. Raemaekers
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  3. H. M. J. van Baar
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  4. B. E. de Pauw
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  5. A. M. Horrevorts
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Kramers, C., Raemaekers, J.M.M., van Baar, H.M.J. et al. Sweet's syndrome as the presenting symptom of hairy cell leukemia with concomitant infection by Mycobacterium kansasii. Ann Hematol 65, 55–58 (1992). https://doi.org/10.1007/BF01715129

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  • DOI: https://doi.org/10.1007/BF01715129

Key words

  • Sweet's syndrome
  • Hairy cell leukemia
  • Mycobacterial disease