Summary
In the therapeutically important range (100–200μg/ml), suramin was found to increase the phagocytic activity of human monocytes (measured by the uptake ofSaccharomyces cerevisiae and sensitized sheep red blood cells) in vitro. Suramin itself was a chemotactic signal for monocytes and increased the chemiluminescence of neutrophil granulocytes. Suramin seems to act via the ATP-binding P2 receptors of human phagocytes.
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