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Streptococcal toxic shock syndrome in a postpartum woman. Case report and review of the literature

Streptokokken-Toxic-Shock-Syndrom bei einer Frau im Wochenbett: Kasuistik und Literaturübersicht

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Summary

A case of streptococcal toxic shock syndrome in a 29-year-old postpartum woman is described. The patient presented with hypotension, coagulation defects, adult respiratory distress syndrome and scarlet exanthema as a complication of hemolytic group A streptococcal endometritis. One hundred and twenty-two other cases of streptococcal toxic shock syndrome in the literature are reviewed and the criteria of the syndrome discussed. Streptococcal toxic shock syndrome seems to be increasing along with more frequent invasive streptococcal infections in several countries. It is therefore important to recognize and treat the infection as early as possible to minimize the risk of mortality.

Zusammenfassung

Bei einer 29jährigen Frau trat im Wochenbett ein durch Streptokokken verursachtes Toxic Shock Syndrom auf, das durch Hypotonie, Gerinnungsstörung, Erwachsenen-Respiratory Distress Syndrom und Scharlach-Exanthem als Komplikation einer A-Streptokokken-Endometritis charakterisiert war. Wir haben 122 andere Fälle von Toxic Shock Syndrom aus der Literatur überprüft und die diagnostischen Kriterien diskutiert. Mit der Zunahme an Streptokokkeninfektionen werden in verschiedenen Ländern häufiger Fälle von Toxic Shock Syndrom beobachtet. Es ist wichtig, die Infektion so früh wie möglich zu erkennen und zu behandeln, um das Mortalitätsrisiko zu vermindern.

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References

  1. Strömberg, A., Romanus, V., Burman, L. G. Outbreak of group A streptococcal septicemia in Sweden: an epidemiological and clinical study. J. Infect. Dis. 164 (1991) 595–598.

    Google Scholar 

  2. Martin, P., Høiby, E. Streptococcal serogroup A in Norway 1987–1988. Scand. J. Infect. Dis. 22 (1990) 421–429.

    Google Scholar 

  3. Hoge, C., Schwartz, B., Talkington, D. The changing epidemiology of invasive group A streptococcal infections and the emergence of streptococcal toxic shock-like syndrome. JAMA 269 (1993) 384–389.

    Google Scholar 

  4. Willoughby, R., Greenberg, R. The toxic shock syndrome and streptococcal pyrogenic toxins. Ann. Intern. Med. 98 (1983) 559.

    Google Scholar 

  5. Norrby-Teglund, A., Newton, D., Kotb, M., Holm, S., Norgren, M. Superantigenic properties of the group A streptococcal exotoxin SpeF (MF). Infect. Immun. 62 (1994) 5227–5233.

    Google Scholar 

  6. The Working Group on Severe Streptococcal Infections Defining the group A streptococcal toxic shock syndrome. JAMA 269 (1993) 390–391.

    Google Scholar 

  7. Rubino, D., Gorman, S., Timmons, J., Leikin, J. Streptococcal toxic shock-like syndrome presenting with hypoglycemia and reversible paralysis. Am. J. Emerg. Med. 11 (1993) 239–242.

    Google Scholar 

  8. Köhler, W. Streptococcal toxic shock syndrome. Zentralbl. Bakt. 272 (1990) 257–264.

    Google Scholar 

  9. Todd, J., Fishaut, M. Toxic shock syndrome associated with phage group I staphylococci. Lancet ii (1978) 1116–1118.

    Google Scholar 

  10. Toxic shock syndrome, United States, 1970–1982. MMWR 31 (1982) 201–204.

    Google Scholar 

  11. Johnson, L., L'Italier, J., Schlievert, P. Streptococcal pyrogenic exotoxin type A (scarlet fever toxin) is related toStaphylococcus aureus enterotoxin B. MGG 203 (1986) 354–356.

    Google Scholar 

  12. Bohach, G., Fast, D., Nelson, R., Schlievert, P. Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illnesses. Crit. Rev. Microbiol. 17 (1990) 251–272.

    Google Scholar 

  13. Shulman, S. Severe group A streptococcal infections. Crit. Care Med. 21 (1993) 314–315.

    Google Scholar 

  14. Ikejima, T., Okusawa, S., Van der Meer, J., Dinarello, C. Toxic shock syndrome is mediated by interleukin 1 and tumor necrosis factor. Rev. Infect. Dis. 11, Suppl. 1 (1989) 316–317.

    Google Scholar 

  15. Nadal, D., Lauener, R., Braegger, C., Kaufhold, A., Simma, B., Lütticken, R., Seger, R. T-cell activation and cytokine release in streptococcal toxic shock-like syndrome. J. Pediatr. 122 (1993) 727–729.

    Google Scholar 

  16. Stevens, D., Tanner, M., Winship, J., Swarts, R., Ries, K., Schlievert, P., Kaplan, E. Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin A. N. Engl. J. Med. 321 (1989) 1–8.

    Google Scholar 

  17. Cone, L., Woodard, D., Schlievert, P., Tomory, G. Clinical and bacteriologic observations of a toxic shock-like syndrome due toStreptococcus pyogenes. N. Engl. J. Med. 317 (1987) 146–149.

    Google Scholar 

  18. Bartter, T., Dascal, A., Carrol, K., Curley, F. Toxic strep syndrome. Arch. Intern. Med. 148 (1988) 1421–1424.

    Google Scholar 

  19. MacLaurin, J. Spontaneous streptococcal myositis associated with disseminated intravascular coagulopathy. J. Am. Osteopath. Ass. 76 (1977) 675–678.

    Google Scholar 

  20. Paraskevaides, E., Wilson, C. Fatal disseminated intravascular coagulation secondary to streptococcal cervicitis. Eur. J. Obstet. Gynecol. Reprod. Biol. 29 (1988) 39–40.

    Google Scholar 

  21. Shaunak, S., Wendon, J., Monteil, M., Gordon, A. Septic scarlet fever due toStreptococcus pyogenes cellulitis. Q. J. Med. 69 (1988) 921–925.

    Google Scholar 

  22. Bollaert, P., Bauer, P., Lambert, H., Laprevote-Heully, M., Burdin, J., Larcan, A. Septicémie fulminante à streptocoque du group A en fin de grossesse. Presse Méd. 17 (1988) 1816–1817.

    Google Scholar 

  23. Hribalova, V. Streptococcus pyogenes and the toxic shock syndrome. Ann. Intern. Med. 108 (1988) 772.

    Google Scholar 

  24. Acharya, U., Lamont, C., Cooper, K. Group A beta-haemolytic streptococcus causing disseminated intravascular coagulation and maternal death. Lancet i (1988) 595.

    Google Scholar 

  25. Kavi, J., Wise, R. Group A beta-hemolytic streptococcus causing disseminated intravascular coagulation and maternal death. Lancet i (1988) 993–994.

    Google Scholar 

  26. Swingler, G., Bigrigg, M., Hewitt, B., McNulty, C. Disseminated intravascular coagulation associated with group A streptococcal infection in pregnancy. Lancet i (1988) 1456–1457.

    Google Scholar 

  27. Connolly, T. J., Pavelka, D., Lanspa, E., Connolly, T. L. Toxic shock-like syndrome associated with necrotizingStreptococcus pyogenes infection. Henry Ford Hosp. Med. J. 37 (1989) 69–72.

    Google Scholar 

  28. Fikrig, E., Worthington, M., Lefkowitz, L. Septic shock and acute respiratory distress syndrome after salpingitis caused byStreptococcus pyogenes group A. South. Med. J. 82 (1989) 634–635.

    Google Scholar 

  29. Gaworzewska, E., Hallas, G. Group A streptococcal infections and a toxic shock-like syndrome. N. Engl. J. Med. 321 (1989) 1545–1546.

    Google Scholar 

  30. Köhler, W., Nestler, J., Knöll, H., Schneider, J., Schau, H. Streptococcal toxic shock syndrome. Z. Gesamte Inn. Med. 44 (1989) 725–731.

    Google Scholar 

  31. Schattner, A., Hay, E., Lifschitz-Mercer, B., Gorbacz, S., Bentwich, Z. Fulminant streptococcal myositis. Ann. Emerg. Med. 18 (1989) 320–322.

    Google Scholar 

  32. Shearin, R., Boehlke, J., Karanth, S. Toxic shock-like syndrome associated with Bartholin's gland abscess. Am. J. Obstet. Gynecol. 160 (1989) 1073–1074.

    Google Scholar 

  33. Begovac, J., Marton, E., Lisic, M., Beus, I., Bozinovic, D., Kuzmanovic, N. Group A beta-hemolytic streptococcal toxic shock-like syndrome. Pediatr. Infect. Dis. J. 9 (1990) 369–370.

    Google Scholar 

  34. Knezevich, S., Torch, M. Streptococcal toxic shock-like syndrome leading to bilateral lower extremity compartment syndrome and renal failure. Clin. Orthop. 254 (1990) 247–250.

    Google Scholar 

  35. Chomarat, M., Chapuis, C., Lepape, A., Bernard, F. Two cases of severe infection with beta-hemolytic group A streptococci associated with a toxic shock-like syndrome. Eur. J. Clin. Microbiol. Infect. Dis. 9 (1990) 901–903.

    Google Scholar 

  36. Christen, R., Moser, R., Schlup, P., Neftel, K. Fulminant group A streptococcal infections. Klin. Wochenschr. 68 (1990) 427–430.

    Google Scholar 

  37. Gallo, U. Toxic streptococcal syndrome. Ann. Emerg. Med. 19 (1990) 1332–1334.

    Google Scholar 

  38. Herold, A. Group A beta-hemolytic streptococcal toxic shock from a mild pharyngitis. J. Fam. Pract. 31 (1990) 549–551.

    Google Scholar 

  39. Lersch, C., Gain, T., v. Siemens, M., Hagenmüller, F., Clausen, M. Toxic shock-like syndrome due to severe hemolytic group A streptococcal infection. Klin. Wochenschr. 68 (1990) 523–525.

    Google Scholar 

  40. McGlashan, J. Do streptococci cause toxic shock? BMJ 301 (1990) 1391–1392.

    Google Scholar 

  41. Whitted, W., Yeomans, E., Hankins, C. Group A beta-hemolytic streptococcus as a cause of toxic shock syndrome. J. Reprod. Med. 35 (1990) 558–560.

    Google Scholar 

  42. Bradley, J., Schlievert, P., Glenn Sample, T. Streptococcal toxic shock-like syndrome as a complication of varicella. Ped. Infect. Dis. J. 10 (1991) 77–79.

    Google Scholar 

  43. Margolis, D., Horlick, S. Group A streptococcus-induced bullous toxic shock-like syndrome. J. Amer. Acad. Dermatol. 24 (1991) 786–787.

    Google Scholar 

  44. Torres-Martinez, C., Mehta, D., Butt, A., Levin, M. Streptococcus associated toxic shock. Arch. Dis. Child 67 (1992) 126–130.

    Google Scholar 

  45. Nathan, L., Peters, M., Ahmed, A., Leveno, K. The return of life-threatening puerperal sepsis caused by group A streptococci. Am. J. Obstet. Gynecol. 169 (1993) 571–572.

    Google Scholar 

  46. Wood, T., Potter, M., Jonasson, O. Streptococcal toxic shock-like syndrome. Ann. Surg. 217 (1993) 109–114.

    Google Scholar 

  47. Stegmayr, B., Björck, S., Holm, S., Nisell, J., Rydvall, A., Settergren, B. Septic shock induced by group A streptococcal infection: clinical and therapeutic aspects. Scand. J. Infect. Dis. 24 (1992) 589–597.

    Google Scholar 

  48. Craigen, M., Wallace, W. Toxic shock-like syndrome due to streptococcal hand infection. J. R. Coll. Surg. Edinb. 37 (1992) 269–270.

    Google Scholar 

  49. Cherchi, G., Kaplan, E., Schlievert, P., Bitti, A., Orefici, G. First reported case ofStreptococcus pyogenes infection with toxic shock-like syndrome in Italy. Eur. J. Clin. Microbiol. Infect. Dis. 11 (1992) 836–838.

    Google Scholar 

  50. Boyle, M., Singer, J. Necrotizing myositis and toxic strep syndrome in a pediatric patient. J. Emerg. Med. 10 (1992) 577–579.

    Google Scholar 

  51. Chapnick, E., Gradon, J., Lutwick, L., Kim, J., Levi, M., Kim, M., Schlievert, P. Streptococcal toxic shock syndrome due to noninvasive pharyngitis. Clin. Infect. Dis. 14 (1992) 1074–1077.

    Google Scholar 

  52. Novotny, W., Faden, H., Mosovich, L. Emergence of invasive group A streptococcal disease among young children. Clin. Pediatr. 31 (1992) 596–601.

    Google Scholar 

  53. Floret, D., Stamm, D., Cochat, P., Delmas, P., Kohler, W. Streptococcal toxic shock syndrome in children. Intensive Care Med. 18 (1992) 175–176.

    Google Scholar 

  54. Snabes, M., Martens, M. A severe puerperal group A streptococcal infection causing a toxic shock-like syndrome. Int. J. Gynaecol. Obstet. 40 (1993) 245–248.

    Google Scholar 

  55. Maher, D., Ostrowski, J. Highly virulentStreptococcus pyogenes rheumatic pancarditis and fatal septicemia with septic shock. J. Infect. 26 (1993) 195–197.

    Google Scholar 

  56. Ejlertsen, T., Porsborg, P. Toxic shock syndrome related to simultaneousStaphylococcus aureus epiglottic abscess and group A streptococcal pharyngitis with bacteremia. APMIS 102 (1994) 956–959.

    Google Scholar 

  57. Chelsom, J., Halstensen, A., Haga, T., Höjby, A. Necrotizing fasciitis due to group A streptococci in western Norway: incidence and clinical features. Lancet 344 (1994) 111–115.

    Google Scholar 

  58. Smith, R., Schlievert, P., Himelright, I., Baddour, L. Dual infection withStaphylococcus aureus andStreptococcus pyogenes causing toxic shock syndrome. Diagn. Microbiol. Infect. Dis. 19 (1994) 245–247.

    Google Scholar 

  59. Jevon, G., Dunne, M., Hawkins, H., Armstrong, D., Musser, J. Fatal group A streptococcal meningitis and toxic shock-like syndrome: case report. Clin. Infect. Dis. 18 (1994) 91–93.

    Google Scholar 

  60. Al Mazrou, A. Streptococcal toxic shock-like syndrome: case report and review of the literature. Ann. Trop. Paediatr. 14 (1994) 145–148.

    Google Scholar 

  61. Cohen, E., Korzets, A., Tsalihin, Y., Zevin, D., Gafter, U., Zahivi, I. Streptococcal toxic shock syndrome complicating necrotizing fasciitis in a renal transplant patient. Nephrol. Dial. Transplant. 9 (1994) 1498–1499.

    Google Scholar 

  62. Wann, S.-R., Yen, M.-Y., Chen, Y.-S., Wang, J.-H., Huang, W.-K., Huang, T.-S., Wang, J.-H., Liu, Y.-C., Cheng, D.-L. Streptococcal toxic shock syndrome in southern Taiwan. J. Formos. Med. Assoc. 94 (1995) 172–177.

    Google Scholar 

  63. Keyser, P., Campbell, W. Toxic strep syndrome associated with group C streptococcus. Arch. Intern. Med. 152 (1992) 883–884.

    Google Scholar 

  64. Aitken, D., Mackett, T., Smith, L. The changing pattern of hemolytic streptococcal gangrene. Arch. Surg. 117 (1982) 561–567.

    Google Scholar 

  65. Meleney, F. Hemolytic streptococcal gangrene. Arch. Surg. 9 (1924) 317–364.

    Google Scholar 

  66. Christie, A. Infectious diseases. Churchill Livingstone, London 1987, pp. 1281–1288.

    Google Scholar 

  67. Bisno, A. Streptococcus pyogenes. In:Mandell, G., Douglas, R., Bennett, J. (eds.): Principles and practice of infectious diseases. John Wiley and Sons, New York 1985, pp. 1124–1133.

    Google Scholar 

  68. Barry, W., Hudgins, L., Donta, S., Pesanti, E. Intravenous immunoglobulin therapy for toxic shock syndrome. JAMA 267 (1992) 3315–3316.

    Google Scholar 

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Jorup-Rönström, C., Hofling, M., Lundberg, C. et al. Streptococcal toxic shock syndrome in a postpartum woman. Case report and review of the literature. Infection 24, 164–167 (1996). https://doi.org/10.1007/BF01713330

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