Skip to main content
SpringerLink
Log in

HLA und Schilddrüsencarcinom

HLA and thyroid cancer

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

HLA typing was performed in 51 patients to analyse the pathogenetic background of differentiated and medullary thyroid carcinomas. A higher incidence of Bw62 and DR5 was observed in patients with papillary carcinoma (n=24), DRw6 antigen in follicular carcinoma (n=13), and DR3 antigen in patients with medullary carcinoma (n=11). The DR3 antigen was present in one of two patients with a familial history of medullary thyroid carcinoma. Therefore, HLA typing is not suitable as a screening method for the detection of early thyroid carcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

FC:

follikuläres Schilddrüsencarcinom

HLA:

human leucocyte antigens

MC:

medulläres (C-Zell) Carcinom

PC:

papilläres Schilddrüsencarcinom

Literatur

  1. Allanic H, Fauchet R, Lorcy Y, Gueguen M, le Guerrier A-M, Genetet A (1983) A prospective study of the relationship between relapse of hyperthyroid Graves' disease after antithyroid drugs and HLA haplotype. J Clin Endocrinol Metab 57:719–722

    Article  Google Scholar 

  2. Armitage P (1973) Statistical methods in medical research. Blackwell Scientific Publications

  3. Bech K, Lumholtz B, Nerup J, Thomsen M, Platz P, Ryder LP, Svejgaard A, Siersbaek-Nielsen K, Hansen JM, Hannover Larsen J (1977) HLA antigens in Graves' disease. Acta Endocrinol 86:510–516

    CAS  PubMed  Google Scholar 

  4. Bliddal H, Bech K, Feldt-Rasmussen, U, Thomsen M, Ryder LP, Hansen JM, Siersbaek-Nielsen K, Friis T (1982) Thyroid-stimulating immunoglobulins in Hashimoto's thyroiditis measured by radioreceptor assay and adenylate cyclase stimulation and their relationship to HLA-D alleles. J Clin Endocrinol Metab 55:995–998

    Article  CAS  PubMed  Google Scholar 

  5. Caillou B, Talbot M, Schlumberger M, Rougier P, Bellet D, Travagli JP (1983) Usefulness of new methodological and conceptual approaches in thyroid carcinoma (especially in medullary carcinoma): Acta Endocrinol 102 (Suppl 252):29–31

    Google Scholar 

  6. Camiel MR, Mulé JE, Alexander LL, Benninghoff DL (1968) Association of thyroid carcinoma with Gardner's syndrome in siblings: New Engl J Med 278:1056–1058

    Article  CAS  PubMed  Google Scholar 

  7. Christensen SB, Ljungberg O (1983) Familial occurrence of papillary thyroid carcinoma. Br J Surg 70:508–509

    Article  CAS  PubMed  Google Scholar 

  8. Dralle H, Altenähr E (1979) Pituitary adenoma, primary parathyroid hyperplasia and papillary (non-medullary) thyroid carcinoma, a case of multiple endocrine neoplasia (MEN). Virchows Arch [Pathol Anat] 381:179–187

    Article  CAS  Google Scholar 

  9. Eisenbarth G, Wilson P, Ward F, Lebovitz HE (1978) HLA type and occurrence of disease in familial polyglandular failure. New Engl J Med 298:92–94

    Article  CAS  PubMed  Google Scholar 

  10. Farid NR, Stone E, Johnsen G (1980) Graves' disease and HLA: clinical and epidemiological associations. Clin Endocrinol 13:535–544

    Article  CAS  Google Scholar 

  11. Farid NR, Sampson L, Moens H, Barnard JM (1981) The association of goitrous autoimmune thyroiditis with HLA-DR5. Tissue Antigens 17:265–268

    Article  CAS  PubMed  Google Scholar 

  12. Flannigan GM, Clifford RP, Winslet M, Lawrence DAS, Fiddian RV (1983) Simultaneous presentation of papillary carcinoma of thyroid in a father and son. Br J Surg 70:181–182

    Article  CAS  PubMed  Google Scholar 

  13. Grumet FC, Payne RO, Konishi J, Kriss JP (1974) HL-A antigens as markers for disease susceptibility and autoimmunity in Graves' disease. J Clin Endocrinol Metab 39:1115–1119

    Article  CAS  PubMed  Google Scholar 

  14. Keshgegian AA, Enterline HT (1978) Gardner's syndrome with duodenal adenomas, gastric adenomyoma and thyroid papillary — follicular adenocarcinoma. Dis Colon Rectum 21:255–260

    Article  CAS  PubMed  Google Scholar 

  15. Lacour J, Vignalou J, Perez R, Gérard-Marchant R (1973) Epithelioma papillaire du corps thyroide. Nouv Press Med 2:2249–2252

    CAS  Google Scholar 

  16. Lloyd RV, Johnson TL, Blaivas M, Sisson JC, Wilkson BS (1985) Detection of HLA-DR antigens in paraffin-embedded thyroid epithelial cells with a monoclonal antibody. Am J Pathol 120:106–111

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Ljungberg O, Bondeson L, Bondeson A-G (1984) Differentiated thyroid carcinoma, intermediate type: a new tumor entity with features of follicular and parafollicular cell carcinoma. Hum Pathol 15:218–228

    Article  CAS  PubMed  Google Scholar 

  18. Moens H, Farid NR (1978) Hashimoto's thyroiditis is associated with HLA-DRw3. New Engl J Med 299:133–134

    Article  CAS  PubMed  Google Scholar 

  19. Moens H, Barnard JM, Bear J, Farid NR (1979) The association of HLA-B8 with atrophic thyroiditis. Tissue Antigens 13:342–348

    Article  CAS  PubMed  Google Scholar 

  20. Nemec J, Soumar J, Zamrazil V, Pohunková D, Motlik K, Mirejovsky P (1975) Familial occurrence of differentiated (non-medullary) thyroid cancer. Oncology 32:151–157

    Article  CAS  PubMed  Google Scholar 

  21. Panza N, Vecchio LD, Maio M, de Felice M, Lombardi G, Minozzi M, Zappacosta S (1982) Strong association between an HLA-DR antigen and thyroid carcinoma. Tissue Antigens 20:155–158

    Article  CAS  PubMed  Google Scholar 

  22. Phade VR, Lawrence WR, Max MH (1981) Familial papillary carcinoma of the thyroid. Arch Surg 116:836–837

    Article  CAS  PubMed  Google Scholar 

  23. Rotter JI, Rimoin DL (1978) Heterogeneity in diabetes mellitus — update, 1978. Diabetes 27:599–605

    Article  CAS  PubMed  Google Scholar 

  24. Schernthaner G, Schleusener H, Kotulla P, Finke R, Wenzel B, Mayr WR (1980) Prediction of relapse or long-term remission in hyperthyroid Graves' disease. Lancet 2:373–374

    Article  CAS  PubMed  Google Scholar 

  25. Schleusener H, Schernthaner G, Mayr WR, Kotulla P, Bogner U, Finke R, Meinhold H, Koppenhagen K, Wenzel KW (1983) HLA-DR3 and HLA DR5 associated thyrotoxicosis — two different types of toxic diffuse goiter. J Clin Endocrinol Metab 56:781–785

    Article  CAS  PubMed  Google Scholar 

  26. Sipple JH (1961) The association of phaeochromocytoma with carcinoma of the thyroid. Am J Med 31:163–166

    Article  Google Scholar 

  27. Smith WG, Kern BB (1973) The nature of the mutation in familial multiple polyposis: papillary carcinoma of the thyroid, brain tumors, and familial multiple polyposis. Dis Colon Rectum 16:264–271

    Article  CAS  PubMed  Google Scholar 

  28. Sridama V, Hara Y, Fauchet R, DeGroot LJ (1985) Association of differentiated thyroid carcinoma with HLA-DR7. Cancer 56:1086–1088

    Article  CAS  PubMed  Google Scholar 

  29. Steiner AL, Goorman AD, Powers SR (1968) Study of a kindred with phaeochromocytoma, medullary thyroid carcinoma, hyperparathyroidism and Cushing's disease: multiple endocrine neoplasia, type 2. Medicine 47:371–409

    Article  CAS  PubMed  Google Scholar 

  30. Terasaki T, McCurdy B, McClelland J (1972) Microdroplet lymphocyte cytotoxicity test. In: Ray JG, Scott RC, Hare DB, Harris CE, Kayhoe DE (eds) Manual of tissue typing techniques. NIH, Bethesda, pp 50–53

    Google Scholar 

  31. Thompson JS, Harned RK, Anderson JC, Hodgson PE (1983) Papillary carcinoma of the thyroid and familial polyposis coli. Dis Colon Rectum 183:583–585

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Abdominal- und Transplantationschirurgie der Medizinischen Hochschule Hannover, Germany

    H. Dralle

  2. Abteilung für Immunhaematologie und Transfusionsmedizin der Medizinischen Hochschule Hannover, Germany

    M. Robin-Winn

  3. Institut für Nuklearmedizin und spezielle Biophysik der Medizinischen Hochschule Hannover, Germany

    L. Reilmann & A. Laue

  4. Institut für Biometrie der Medizinischen Hochschule Hannover, Germany

    M. Török

Authors
  1. H. Dralle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Robin-Winn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Reilmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Laue
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Török
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

In Auszügen vorgetragen auf dem 15. Acta Endocrinologica-Kongreß, 5.–9. August 1985, Helsinki

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dralle, H., Robin-Winn, M., Reilmann, L. et al. HLA und Schilddrüsencarcinom. Klin Wochenschr 64, 522–525 (1986). https://doi.org/10.1007/BF01713060

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01713060

Key words

Search

Navigation