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Heatstroke: A new look at an ancient disease

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References

  1. Jarcho S (1967) A Roman experience with heat stroke in 24 B.C. Bull NY Acad Med 43:767–768

    Google Scholar 

  2. Levick JJ (1859) Remarks on sunstroke. Am J Med Sci 73:40–55

    Google Scholar 

  3. Malamud N, Haymaker W, Custer RP (1946) Heat stroke: a clinico-pathologic study of 125 fatal cases. Milit Surg 99:397–449

    Google Scholar 

  4. Simon HB (1993) Hyperthermia. N Engl J Med 329:483–487

    Google Scholar 

  5. Austin MG, Berry JW (1956) Observations on one hundred cases of heatstroke. JAMA 161:1525–1529

    Google Scholar 

  6. Hart GR, Anderson RJ, Crumpler CP, Shulkin A, Reed G, Knochel JP (1981) Epidemic classical heatstroke: clinical characteristics and course of 28 patients. Medicine (Baltimore) 61: 189–197

    Google Scholar 

  7. Anonymous (1989) Endotoxins in heatstroke (Editorial). Lancet II: 1137–1138.

  8. Ghaznawi HI, Ibrahim MA (1987) Heatstroke and heat exhaustion in pilgrims performing the Haj (annual pilgrimage) in Saudi Arabia. Ann Saudi Med 7:323–326

    Google Scholar 

  9. Jimenez-Mejias ME, Montano Diaz M, Villalonga J, Bollaini Tienda E, Lopez Pardo F, Pineda JA, Gonzalez de la Puenta MA (1990) Classical heatstroke in Spain. Analysis of a series of 78 cases. Med Clin (Barc) 94:481–486

    Google Scholar 

  10. Jone TS, Liang AP, Kilbourne EM, Griffin MR, Patriarca PA, Wassilak SGF, Mullan R, Herrick RF, Donnell HD, Choi K, Thacker SB (1982) Morbidity and mortality associated with the July 1980 heatwave in St Louis and Kansas City, Mo. JAMA 247: 3327–3331

    Google Scholar 

  11. Bouchama A, Cafege A, DeVol EB, Labdi O, El-Assil K, Seraj M (1991) Ineffectiveness of dantrolene sodium in the treatment of heatstroke. Crit Care Med 19:176–180

    Google Scholar 

  12. O'Donnell TF, Jr, Clowes GHA Jr (1972) The circulatory abnormalities of heatstroke. N Engl J Med 287:734–737

    Google Scholar 

  13. Bouchama A, Cafege A, Robertson W, Al-Dossary S, El-Yazigi A (1991) Mechanisms of hypophosphatemia in humans with heatstroke. J Appl Physiol 71:328–332

    Google Scholar 

  14. Bouchama A, Al-Hussein K, Adra C, Rezeig M, Al-Shail E, Al-Sedairy S (1992) Distribution of peripheral blood leukocytes in acute heatstroke. J Appl Physiol 73:405–409

    Google Scholar 

  15. Wybdham CH, Strydom NB, Cooke HM, Maritz JS, Morrison JF, Fleming PW, Ward JS (1959) Methods of cooling subjects with hyperpyrexia. J Appl Physiol 14:771–776

    Google Scholar 

  16. Dinarello CA, Cannon JG, Wolff SM (1988) New concepts on the pathogenesis of fever. Rev Infect Dis 10:168–189

    Google Scholar 

  17. Rowell LB (1983) Cardiovascular aspects of human thermoregulation. Circ Res 52:367–379

    Google Scholar 

  18. Gathiram P, Wells MT, Raidoo D, Brock-Utne JG, Gaffin SL (1988) Portal and systemic plasma lipopolysaccharide concentrations in heat-stressed primates. Circ Shock 25:223–230

    Google Scholar 

  19. Bouchama A, Parhar RS, El-Yazigi A, Sheth K, Al-Sedairy S (1991) Endotoxemia and release of tumor necrosis factor and interleukin-1α in acute heatstroke. J Appl Physiol 70:2640–2644

    Google Scholar 

  20. Bouchama A, Al-Sedairy S, Siddiqui S, Shail E, Rezeig M (1993) Elevated pyrogenic cytokines in heatstroke. Chest 104:1498–1502

    Google Scholar 

  21. Bouchama A, El-Yazigi A, Yusuf A, Al-Sedairy S (1993) Alteration of taurine homeostasis in acute heatstroke. Crit Care Med 21:551–554

    Google Scholar 

  22. El-Kassimi FA, Al-Mashadani S, Abdullah AK, Akhtar J (1986) Adult respiratory distress syndrome and disseminated intravascular coagulation complicating heatstroke. Chest 90:571–574

    Google Scholar 

  23. Pettigrew RT, Galt JM, Ludgate CM, Horn DB, Smith AN (1974) Circulatory and biochemical effects of whole body hyperthermia. Br J Surg 61:727–730

    Google Scholar 

  24. Bynum GD, Pandolf KB, Schuette WH, Goldman RF, Lees DE, Whang-Peng J, Atkinson ER, Bull JM (1978) Induced hyperthermia in sedated humans and the concept of critical thermal maximum. Am J Physiol 235:R228-R236

    Google Scholar 

  25. Shibolet S, Fisher S, Gilat T, Bank H, Heller H (1962) Fibrinolysis and hemorrhages in fatal heatstroke. N Engl J Med 266:169–173

    Google Scholar 

  26. Beard MEJ, Hickton CM (1982) Haemostasis in heat stroke. Br J Haematol 52:269–274

    Google Scholar 

  27. Perchick JS, Winkelstein A, Shadduck RK (1975) Disseminated intravascular coagulation in heat stroke. Response to heparin therapy. JAMA 231:480–483

    Google Scholar 

  28. Chao TC, Sinniah R, Pakiam JE (1981) Acute heatstroke deaths. Pathology 13:145–156

    Google Scholar 

  29. Sohal RS, Sun SC, Colcolough HL, Burch GE (1968) Heatstroke: an electron microscopic study of endothelial cell damage and disseminated intravascular coagulation. Arch Intern Med 122:43–47

    Google Scholar 

  30. Bouchama A, Hammami M, Siddiqui S, Haq A, Al-Sedairy S (1993) Evidence of endothelial cell activation/injury in response to sustained hyperthermia (Abstract). 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, October 17–20, 1993 New Orleans, Louisiana, USA, 220:554

    Google Scholar 

  31. Bouchama A, Jackson J, Khan J (1993) Release of Von Willebrand factor (VWF-Ag) in heatstroke patients (abstract). Am Rev Respir Dis 147:A346

    Google Scholar 

  32. Gathiram P, Wells MT, Brock-Utne JG, Gaffin SL (1987), Antilipopolysaccharide improves survival in primates subjected to heatstroke. Circ Shock 23:157–164

    Google Scholar 

  33. Beutler B, Grau GE (1993) Tumor necrosis factor in the pathogenesis of infectious diseases. Crit Care Med 21: S423-S435

    Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, King Faisal Specialist Hospital and Research Centre, 11211, Riyadh, Saudi Arabia

    A. Bouchama

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  1. A. Bouchama
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Bouchama, A. Heatstroke: A new look at an ancient disease. Intensive Care Med 21, 623–625 (1995). https://doi.org/10.1007/BF01711537

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