Abstract
We report on five patients in whom long-term sedation with isoflurane for up to 7 days was used successfully. Serum inorganic fluoride concentrations were measured daily. The concentrations ranged from 12 mmol l−1 to 29 mmol l−1. These were well below the described renal toxic level of 50 mmol l−1. There was no deterioration in renal function attributable to the use of isoflurane.
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Osborne, M.A., Eddleston, J.M. & McNicoll, W. Inorganic fluoride concentration after long-term sedation with isoflurane. Intensive Care Med 22, 677–682 (1996). https://doi.org/10.1007/BF01709746
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DOI: https://doi.org/10.1007/BF01709746