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Sotalol poisoning associated with asystole


Sotalol overdose has special features because this beta-blocker has the potential to lenghten the Q-T interval and to initiate severe arrhythmias such as ventricular tachycardia or fibrillation. We describe the case of a 70-year-old woman who ingested 6.72 g sotalol with suicide attempt. Despite administration of activated charcoal, glucagon, atropine and isoprenaline, two episodes of asystole occurred, requiring cardiopulmonary resuscitation. Further treatment included ventricular pacing and dopamine. The patient recovered without neurologic nor cardiac sequelae.

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Adlerfliegel, F., Leeman, M., Demaeyer, P. et al. Sotalol poisoning associated with asystole. Intensive Care Med 19, 57–58 (1993).

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Key words

  • Beta-blockers
  • Overdosage
  • Arrhythmias