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In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides againstStreptococcus pneumoniae andHaemophilus influenzae

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Abstract

The purpose of this study was to compare the in vitro activity of a new ketolide, HMR 3004 (RU64004), to that of three macrolides and one azalide against 608 Streptococcus pneumoniae and 202 Haemophilus influenzae. Macrolide-resistant pneumococci were susceptible to HMR 3004, even if they were resistant to clindamycin. Against Haemophilus influenzae, HMR 3004 and azithromycin were nearly identical in potency; the macrolides were 8- to 16-fold less active. HMR 3004 may be useful for treating respiratory tract infections if sufficient concentrations can be achieved at the local sites of infection.

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Authors and Affiliations

  1. The Clinical Microbiology Institute, 9725 S.W. Commerce Circle, Suite A-l, 97070, Wilsonville, Oregon, USA

    A. L. Barry, P. C. Fuchs & S. D. Brown

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  1. A. L. Barry
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  2. P. C. Fuchs
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  3. S. D. Brown
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Barry, A.L., Fuchs, P.C. & Brown, S.D. In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides againstStreptococcus pneumoniae andHaemophilus influenzae . Eur. J. Clin. Microbiol. Infect. Dis. 16, 767–769 (1997). https://doi.org/10.1007/BF01709263

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  • DOI: https://doi.org/10.1007/BF01709263

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