Abstract
A hospital-based matched case-control study was conducted in order to identify risk factors for the development of bloodstream infections in adult hospitalized patients. Between January 1993 and December 1994, 264 episodes of bloodstream infection were evaluated. Significant variables identified by univariate analysis were included in a multivariate model that showed that central venous catheter [odds ratio (OR), 6.71], poor performance status (OR, 3.40), weight loss (OR, 2.47), hematologic diseases (OR, 2.24), and previous antimicrobial therapy (OR, 2.12) independently influenced the outcome. The knowledge of modifiable risk factors is useful in the development of strategies that may contribute to the prevention of bloodstream infections.
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Weinstein MP, Towns ML, Quartey SM, Mirrett S, Relmer LG, Parmigiani G, Relier LB: The clinical significance of positive bloo.d culture in the 1990 s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clinical Infectious Diseases (1997) 24:584–602
Pittet D, Wenzel RP: Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths. Archives of Internal of Medicine (1995) 155:1177–1184
Haley RW, Culver DH, White JW, Morgan WN, Emori TG, Munn VP, Hooton TM: The efficacy of infection control programs in preventing nosocomial infections in US hospitals. American Journal of Epidemiology (1985) 121:182–205
Pittet D, Davis CS, Li N, Wenzel RP: Identifying the hospitalized patient at risk for nosocomial bloodstream infection: a population-based study. Proceedings of the Association of American Physicians (1997) 109:58–67
Hospital Infection Program, Center for Infection Diseases, Centers for Disease Control and Prevention: National Nosocomial Infections Surveillance System: NNIS Manual. Public Health Service, US Department of Health and Human Services, Atlanta 1994, pp. XIII-17
Roberts FJ, Geere IW, Goldman A: A three-year study of positive blood cultures, with emphasis on prognosis. Reviews of Infectious Diseases (1991) 13:34–46
Fauci AS, Dale DC, Below JE: Glucocorticosteroid therapy: mechanisms of action and clinical considerations (NIH conference). Annals of Internal Medicine (1976) 84:304–315
Carlisle PS, Gucalp R, Wiernik P: Nosocomial infections in neutropenic cancer patients. Infection Control and Hospital Epidemiology (1993) 14:320–324
Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM: CDC definitions for nosocomial infections, 1988. American Journal of Infection Control (1988) 16:128–140
Lecciones JA, Lee JW, Navarro EE, Witebsky FG, Marshall D, Steinberg SM, Pizzo PA, Walsh TJ: Vascular catheterassociated fungemia in patients with cancer: analysis of 155 episodes. Clinical Infectious Diseases (1992) 14:875–883
Wey SB, Mori M, Pfaller MA, Woolson RF, Wenzel RP: Risk factors for hospital-acquired candidemia. A matched casecontrol study. Archives of Internal Medicine (1989) 149:2349–2353
Shou J, Lappin, Minnard EA, Daiy JM: Total parenteral nutrition, bacterial translocation, and host immune function. American Journal of Surgery (1994) 167:145–150
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Velasco, E., Thuler, L.C.S., Martins, C.A.S. et al. Risk factors for bloodstream infections at a cancer center. Eur. J. Clin. Microbiol. Infect. Dis. 17, 587–590 (1998). https://doi.org/10.1007/BF01708626
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DOI: https://doi.org/10.1007/BF01708626