Abstract
We report here 6 cases of critically ill newborn infants with both RDS and acute renal insufficiency, unresponsive to conventional treatment (furosemide, dopamine). Theophylline, an adenosine antagonist, has been shown to prevent hypoxemia-induced renal insufficiency in rabbits and our patients thus received compassionately a low-dose of theophylline (1 mg·kg−1 IV). Urinary water excretion and creatinine clearances increased significantly in 5 out of 6 neonates, thus suggesting a beneficial role of theophylline in neonatal prerenal failure.
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Huet, F., Semama, D., Grimaldi, M. et al. Effects of theophylline on renal insufficiency in neonates with respiratory distress syndrome. Intensive Care Med 21, 511–514 (1995). https://doi.org/10.1007/BF01706205
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DOI: https://doi.org/10.1007/BF01706205