Abstract
Diffusion-weighted and susceptibility-contrast-enhanced magnetic resonance imaging were used to monitor the development of focal ischemia in cat brain. Diffusion-sensitized imaging was used to assess early ischemic tissue damage which was confirmed for the latest time point (∼12 h) with postmortem histological analysis.T*2-sensitized FLASH was used to measure the first passage of a bolus of FeO particles. Gamma function fitting of ΔR*2-time curves resulted in 2D maps of relative hemodynamic parameters, including cerebral blood volume and flow. The present data provide indications for cerebral blood flow thresholds for acute as well as for delayed ischemic tissue damage.
Similar content being viewed by others
References
Siesjö B (1992) Pathophysiology and treatment of focal cerebral ischemia. J Neurosurg77 169.
Heiss W-D (1992) Experimental evidence of ischemic thresholds and functional recovery.Stroke 23 1668.
LeBihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M (1986) MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders.Radiology 161 401.
Moseley ME, Cohen Y, Mintorovitch J, Chileuitt L, Shimizu H, Kucharczyk J, Wendland MF, Weinstein PR (1990) Early detection of cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy.Magn Reson Med 14 330.
Van Gelderen P, De Vleeschouwer MHM, DesPres D, Pekar J, Van Zijl PCM, Moonen CTW (1994) Water diffusion and acute stroke.Magn Reson Med 31 154.
Verheul HB, Balázs R, Berkelbach van der Sprenkel J-W, Tulleken CAF, Nicolay K, Van Lookeren Campagne M (1993) Temporal evolution of NMDA induced excitotoxicity in the neonatal rat grain measured with1 H nuclear magnetic resonance imaging.Brain Res 618 203.
Verheul HB, Balázs R, Berkelbach van der Sprenkel J-W, Tulleken CAF, Nicolay K, Tamminga KS, VanLookeren Campagne M (1994) Comparison of diffusion-weighted MRI with changes in cell volume in rat model of brain injury.NMR Biomed 7 96–100.
Zhong J, Petroff OAC, Prichard JW, Gore JC (1993) Changes in water diffusion and relaxation in rat cerebrum during status epilepticus.Magn Reson Med 30 241.
Villringer A, Rosen BR, Belliveau JW, Ackerman JL, Lauffer RB, Buxton RB, Chao Y-S, Wedeen VJ, Brady TJ (1988) Dynamic imaging with Lanthanine chelates in normal brain: Contrast due to magnetic susceptibility effects.Magn Reson Med 6 164.
Rosen BR, Belliveau JW, Vevea JM, Brady TJ (1989) Perfusion imaging with NMR contrast agents.Magn Reson Med 14 249.
O'Brien MD, Waltz AG (1973) Transorbital approach for occluding the middle cerebral artery without craniectomy.Stroke 4 201.
Berninger WH, Axel L, Norman D, Napel S, Redington RW (1981) Functional imaging of the brain using computed tomography.Radiology 138 711.
Weisskoff RM, Chesler D, Boxerman JL, Rosen BR (1993) Pitfalls in MR measurement of tissue blood flow with intravascular tracers: which mean transit time?Magn Reson Med 29 553.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Verheul, H.B., Tamminga, K.S., Dijkhuizen, R.M. et al. Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging. MAGMA 2, 367–370 (1994). https://doi.org/10.1007/BF01705274
Issue Date:
DOI: https://doi.org/10.1007/BF01705274