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Comparison of the efficacy of cilofungin, fluconazole and amphotericin B in the treatment of systemicCandida albicans infection in the neutropenic mouse

Wirksamkeit von Cilofungin, Fluconazol und Amphotericin B im Vergleich bei der Behandlung der systemischen Candida albicans-Infektion bei neutropenischen Mäusen

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Summary

The relative efficacies of cilofungin, amphotericin B and fluconazole were compared in the treatment of systemicCandida albicans infection in neutropenic mice. Thirty-one day survival rates were lowest for cilofungin (14.6%), intermediate for amphotericin B (37.6%) and highest for fluconazole (50.5%). Residual tissue infection in surviving animals was observed with all agents, but was heaviest with fluconazole, especially in the kidneys.

Zusammenfassung

Bei der systemischenCandida albicans-Infektion neutropenischer Mäuse wurden die relativen Aktivitäten von Cilofungin, Amphotericin B und Fluconazol verglichen. Die Überlebensraten nach 39 Tagen waren für Cilofungin mit 14,6% am niedrigsten, in einem mittleren Bereich mit Amphotericin B (37,6%) und am höchsten mit Fluconazol (50,5%). Residualinfektionen der Gewebe bei überlebenden Tieren waren bei allen Substanzen zu beobachten, sie waren bei Fluconazol-Anwendung am stärksten ausgeprägt und fanden sich vor allem in den Nieren.

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Authors and Affiliations

  1. Dept. of Microbiology and Division of Infectious Diseases, St. Michael's Hospital, 30 Bond St., M5B 1W8, Toronto, Canada

    R. M. Bannatyne M.B., Ch.B. (Dip. Bact., FRC Path., FRCPC), P. C. Cheng B.Sc. & I. W. Fong M.B., B.S. (FRCPC)

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  1. R. M. Bannatyne M.B., Ch.B.
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  2. P. C. Cheng B.Sc.
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  3. I. W. Fong M.B., B.S.
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Bannatyne, R.M., Cheng, P.C. & Fong, I.W. Comparison of the efficacy of cilofungin, fluconazole and amphotericin B in the treatment of systemicCandida albicans infection in the neutropenic mouse. Infection 20, 168–170 (1992). https://doi.org/10.1007/BF01704614

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