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Glycoprotein B of bovine herpesvirus type 4: Its phylogenetic relationship to gB equivalents of the herpesviruses

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Abstract

In order to estimate the phylogenetic relationship of BHV-4 among the herpesviruses, we have cloned and sequenced its glycoprotein B (gB). The 2.6 kb open reading frame codes for a 874 amino acid long protein. The comparison of its deduced amino acid sequence with those of its counterparts in 19 distinct herpesviruses groups BHV-4 into the γ-herpesvirinae. The calculation of an evolutionary tree emphasized that BHV-4 is more closely related to herpesvirus saimiri (HVS) than to Epstein-Barr virus (EBV). However, in contrast to EBV and HVS, the gB of BHV-4 contains a putative protease cleavage site and 20 potential N-glycosylation sites. The alignment of the amino acid sequences revealed that 10 cysteine and 7 proline residues, as well as the motifs SPF and GQLG, were completely conserved among the 20 investigated gBs.

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Authors and Affiliations

  1. Robert Koch-Institut, Nordufer 20, D-13353, Berlin, Germany

    Michael Goltz, Hermann Broll, Annette Mankertz, Wolfgang Weigelt & Hans-Jörg Buhk

  2. Institut für Virologie der Freien Universität Berlin, D-13353, Berlin, Germany

    Hanns Ludwig & Kerstin Borchers

Authors
  1. Michael Goltz
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  2. Hermann Broll
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  3. Annette Mankertz
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  4. Wolfgang Weigelt
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  5. Hanns Ludwig
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  6. Hans-Jörg Buhk
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  7. Kerstin Borchers
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Goltz, M., Broll, H., Mankertz, A. et al. Glycoprotein B of bovine herpesvirus type 4: Its phylogenetic relationship to gB equivalents of the herpesviruses. Virus Genes 9, 53–59 (1994). https://doi.org/10.1007/BF01703435

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  • DOI: https://doi.org/10.1007/BF01703435

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