Abstract
The neurovirulent strain of influenza A virus, A/NWS/33, is able to infect a large range of cell types, including mouse brain cells, which are not infected by its parent, A/WS/33. This seems to be largely due to the hemagglutinin of A/NWS/33. The complete nucleotide sequence of the HA genes of both strains has been determined and a comparison revealed a number of changes. Analysis showed that the virulence capabilities of the NWS HA involve at least three different mechanisms: (a) loss of a glycosylation site; (b) a change at the cleavage site; and (c) a substitution in HA2, which may increase the pH of fusion.
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The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned accession numbers U08903-4.
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Ward, A.C., de Koning-Ward, T.F. Changes in the hemagglutinin gene of the neurovirulent influenza virus strain A/NWS/33. Virus Genes 10, 179–183 (1995). https://doi.org/10.1007/BF01702599
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DOI: https://doi.org/10.1007/BF01702599