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Nucleotide and deduced amino acid sequence of the canine adenovirus type 1 proteinase

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Abstract

The DNA sequence of an open reading frame (ORF) corresponding to the canine adenovirus type 1 (Can1) proteinase gene was determined. A total of 1171 base pairs were sequenced from the downstream end of theHindIII-A Can1 genomic fragment, including adjacent regions corresponding to the carboxy-terminal portions of the hexon and the DNA-binding proteins. The predicted Can1 proteinase consists of 206 residues (23,325 D) of which 68% are identical and 83% are similar to the sequence of the human Ad2 proteinase. Alignment with the Ad2 proteinase identified a number of conserved residues that could form part of the catalytic triad of the enzyme.

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Authors and Affiliations

  1. Département de Microbiologie, Faculté de Médecine, Université de Sherbrooke, J1H 5N4, Sherbrooke, Québec, Canada

    Faxing Cai & Joseph M. Weber

Authors
  1. Faxing Cai
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  2. Joseph M. Weber
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Additional information

The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession number M72715.

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Cai, F., Weber, J.M. Nucleotide and deduced amino acid sequence of the canine adenovirus type 1 proteinase. Virus Genes 6, 307–312 (1992). https://doi.org/10.1007/BF01702569

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  • DOI: https://doi.org/10.1007/BF01702569

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