Skip to main content
SpringerLink
Log in

Disposition of perfluorooctanoic acid in the rat after single and subchronic administration

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Belisle J, Hagen DF (1980) A method for the determination of perfluorooctanoic acid in blood and other biological samples. Anal Biochem 101: 369–376

    PubMed  Google Scholar 

  • Griffith FD, Long JE (1980) Animal toxicity studies with ammonium perfluorooctanoate. Am Ind Hyg Assoc J 41:576–583

    PubMed  Google Scholar 

  • Guenthner RA, Vietor ML (1962) Surface active materials from perfluorocarboxylic and -sulphonic acids. I&EC Prod Res Develop 3:165–169

    Google Scholar 

  • Hanhijärvi H, Ophaug RH, Singer L (1982) The sexrelated difference in perfluorooctanoate excretion in the rat. Proc Soc Exp Biol Med 171: 50–55

    PubMed  Google Scholar 

  • Hanhijärvi H, Ylinen M, Kojo A, Kosma VM (1987) Elimination and toxicity of perfluorooctanoic acid during subchronic administration in the Wistar rat. Pharmacol Toxicol 61: 66–68

    PubMed  Google Scholar 

  • Johnson JD, Gibson SJ, Ober RE (1984) Cholestyramine-enhanced fecal elimination of 14C in rats after administration of ammonium 14C-perfluorooctanoate or potassium 14C-perfluorooctanesulphonate. Fundam Appl Toxicol 4: 972–976

    PubMed  Google Scholar 

  • Kennedy GL (1985) Dermal toxicity of ammoniumperfluoro-octanoate. Toxicol Appl Pharmacol 81: 348–355

    PubMed  Google Scholar 

  • Kennedy GL, Hall GT, Brittelli MR, Barnes JR, Chen HC (1986) Inhalation toxicity of ammonium perfluorooctanoate. Fd Chem Toxic 24: 1325–1329

    Google Scholar 

  • Ophaug RH, Singer L (1980) Metabolic handling of perfluorooctanoic acid. Proc Soc Exp Biol Med 163: 19–23

    PubMed  Google Scholar 

  • Pastoor TP, Lee KP, Perri MA, Gillies PJ (1987) Biochemical and morphological studies of ammonium perfluorooctanoate-induced hepatomegaly and peroxisome proliferation. Exp Mol Pathol 47: 98–109

    PubMed  Google Scholar 

  • Sargent JW, Seffl RJ (1970) Properties of perfluorinated liquids. Fed Proc 29: 1699–1703

    PubMed  Google Scholar 

  • Shinoda K, Nomura T (1980) Miscibility of fluorocarbon and hydrocarbon surfactants in micelles and liquid mixtures. J Phys Chem 84: 365–369

    Google Scholar 

  • Ubel FA, Sorensen SD, Roach DE (1980) Health status of plant workers exposed to perfluorochemicals — a preliminary report. Am Ind Hyg Assoc J 41: 584–589

    PubMed  Google Scholar 

  • Ylinen M, Hanhijärvi H, Peura P, Rämö O (1985) Quantitative gas chromatographic determination of perfluorooctanoic acid as the benzyl ester in plasma and urine. Arch Environ Contam Toxicol 14: 713–717

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, University of Kuopio, P.O. Box 6, SF-70211, Kuopio, Finland

    Markku Ylinen & Pekka Peura

  2. Department of Pharmacology and Toxicology, University of Kuopio, P.O. Box 6, SF-70211, Kuopio, Finland

    Anneli Kojo

  3. Leiras-Medica, P.O. Box 415, SF-20101, Turku, Finland

    Hannu Hanhijärvi

Authors
  1. Markku Ylinen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anneli Kojo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hannu Hanhijärvi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pekka Peura
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ylinen, M., Kojo, A., Hanhijärvi, H. et al. Disposition of perfluorooctanoic acid in the rat after single and subchronic administration. Bull. Environ. Contam. Toxicol. 44, 46–53 (1990). https://doi.org/10.1007/BF01702360

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01702360

Keywords

Search

Navigation