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Genotoxic effects of erioflorin acetate and erioflorin methacrylate: Sesquiterpene lactones isolated fromPodanthus ovatifolius Lag. (Compositae)

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References

  • Alarc/'on AM, Cea CG, Weigert TG (1986) Clastogenic effect of hippeastidine (HIPP) (1, 2, 3, 4, 4a, 6 hexahydro-10, hydroxy-3, 8, 9, Trimethoxy-5, 10b, ethanophenanthridine). Bull Environ Contam & Toxicology 37: 508–512.

    Google Scholar 

  • Bhakuni DS, Bittner M, Marticorena C, Silva M, Weldt E, Honeisen M (1976) Screening of Chilean plants for anticancer activity. I. Lloydia 39: 225–243.

    Google Scholar 

  • Bruce WR, Heddle JA (1979) The mutagenic activity of 61 agents as determined by the micronucleus, salmonellas and sperm abnormality assays. Can J Genet Cytol 21: 319–334.

    PubMed  Google Scholar 

  • Cea CG, Etcheverry K, Dulout F (1983) Induction of micronuclei in mouse bone-marrow cells by the flavonoid 5, 3′, 4′,-tri-hydroxy-3, 6, 7, 8-tetramethoxy-flavone (THTMF). Mutation Res 119: 339–342.

    PubMed  Google Scholar 

  • Cea CG, Alarcón AM, Weigert TG (1986) Clastogenic effect of maritidine hydrochloride. IRCS Med Sci 14: 90.

    Google Scholar 

  • Cole RJ, Taylor NA, Cole J, Arlett CF (1979) Transplacental effects of chemical mutagens detected by the micronucleus test. Nature 277: 318–319.

    Google Scholar 

  • Countryman PI, Heddle JA (1976) The production of micronuclei from chromosomal aberrations in irradiated cultures of human lymphocytes. Mutation Res 41: 321–332.

    PubMed  Google Scholar 

  • Das RK, Kar RN (1980) Sodium citrate as a substitute for fetal calf serum in the micronucleus test. Stain technol 55: 43–45.

    PubMed  Google Scholar 

  • Duncan AMW, Roneu A, Blakey DH (1983) Diurnal variation in the response of gamma-ray-induced apoptosis in the mouse intestinal epithelium. Cancer Letters 21: 163–166.

    PubMed  Google Scholar 

  • Gnecco S, Poyser JP, Silva M, Sammes SP, Tyler WT (1973) Sesquiterpene lactones fromPodanthus ovatifolius. Phytochemistry 12: 2469–2477.

    Google Scholar 

  • Goetz P, Srán RJ, Dohnalová J (1975) Relationship between experimental results in mammals and man. I Cytogenetic analysis of bone-marrow injury induced by a single dose of cyclophos-phamide. Mutation Res31: 247–254.

    PubMed  Google Scholar 

  • Goldberg MJ, Blakey DH, Bruce WR (1983) Comparison of the effects of 1,2-dimetylhydrazine and cyclophosphamide on micronucleus incidence in bone-marrow and colon. Mutation Res 109: 91–98.

    PubMed  Google Scholar 

  • Hart JW, Harthey-ASP B (1983) Induction of micronuclei in the mouse. Revised timing of the final stage of erythropoiesis. Mutation Res 120: 127–132.

    PubMed  Google Scholar 

  • Hayashei M, Sofuni T, Ishidate MJr (1984) Kinetics of micronucleus formation in relation to chromosomal aberrations in mouse bone-marrow. Mutation Res 127: 129–137.

    PubMed  Google Scholar 

  • Heddle JA, Carrano AV (1977) The DNA content of micronuclei induced in mouse bone-marrow by α-irradiation: evidence that micronuclei arise from acentric chromosomal fragments. Mutation Res 44: 63–69.

    PubMed  Google Scholar 

  • Heddle JA, Hite M, Krikhart B, Mavournin K, Mac-Gregor JT, Newell GW, Salamone MF (1983) The induction of micronuclei as a measure of genotoxicity. Mutation Res 123: 61–118.

    PubMed  Google Scholar 

  • Jenssen D, Ramel C (1980) The micronucleus test as part of a short-term mutagenicity test program for the prediction of carcinogenicity evaluated by 143 agents tested. Mutation Res 75: 191–202.

    PubMed  Google Scholar 

  • Lähdetie J, Parvinen M (1981) Meiotic micronuclei induced by X-rays in early spermatids of the rat. Mutation Res 81: 103–115.

    PubMed  Google Scholar 

  • Mirkova E, Ashby J (1987) Relative distribution of mature erythrocytes, polychromatic erythrocytes (PE) and micronucleated PE on mouse bone-marrow smears: control observations. Mutation Res 182: 203–209.

    PubMed  Google Scholar 

  • Oliver JP, Goldstein AL (1978) A method for removing femora of mice. J Inmunol Meth 19: 289–292.

    Google Scholar 

  • Parvinen M, Lähdetie J, Parvinen LM (1984) Toxic and mutagenic influences on spermatogenesis. Arch Toxicol Supple 7:128–139.

    Google Scholar 

  • Schmid W (1975) The micronucleus test. Mutation Res 31: 9–15.

    PubMed  Google Scholar 

  • Tates AD, Neuteboom I, Hofker M, den Engelsen L (1980) A micronucleus technique for detecting clastogenic effects of mutagen/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo. Mutation Res 74: 11–20.

    PubMed  Google Scholar 

  • Toppari J, Lähdetie J, Harkönen P, Eirola E, Parvinen M (1986) Mutagen effects on rat seminiferous tubules in vitro: Induction of meiotic micronuclei by adriamycin. Mutation Res 171: 149–156.

    PubMed  Google Scholar 

  • Tsuchimoto T, Mather BE (1979) In vivo cytogenetic screening methods for mutagens, with special reference to the micronucleus test. Arch Toxicol 42: 239–248.

    PubMed  Google Scholar 

  • Wild D (1978) Cytogenetic effects in the mouse of 17 chemical mutagens and carcinogens evaluated by the micronucleus test. Mutation Res 56: 319–327.

    PubMed  Google Scholar 

  • Yamamoto KJ, Kikuchi Y (1980) A comparison of diameters of micronuclei induced by clastogens and by spindle poisons. Mutation Res 71: 127–131.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Molecular Biology, Faculty of Biological Sciences and Natural Resources, Chile

    G. Cea, M. Alarcón & G. Weigert

  2. Department of Mathematics, Faculty of Sciences, University of Concepción, P.O. Box 2407 A-10, Concepción, Chile

    R. Sepulveda

Authors
  1. G. Cea
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  2. M. Alarcón
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  3. G. Weigert
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  4. R. Sepulveda
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Cea, G., Alarcón, M., Weigert, G. et al. Genotoxic effects of erioflorin acetate and erioflorin methacrylate: Sesquiterpene lactones isolated fromPodanthus ovatifolius Lag. (Compositae). Bull. Environ. Contam. Toxicol. 44, 19–28 (1990). https://doi.org/10.1007/BF01702357

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  • DOI: https://doi.org/10.1007/BF01702357

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