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Strain- and organ-dependent differences in induction of aryl hydrocarbon hydroxylase activity by 3-methylcholanthrene

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References

  1. Conney AH (1967) Pharmacological implications of microsomal enzyme induction. Pharmacol Rev 19:317–366

    PubMed  Google Scholar 

  2. Gurtoo HL, Bejba N, Minowada J (1975) Properties, inducibility, and improved method of analysis of aryl hydrocarbon hydroxylase in cultured human lymphocytes. Cancer Res 35: 1235–1243

    PubMed  Google Scholar 

  3. Lawrence JA, Aristo W (1983) Effects of methylcholanthrene and benzoanthracene on blastogenesis and aryl hydrocarbon hydroxylase induction in splenic lymphocytes from three inbred strains of mice. Int J Immunopharmacol 5/2:123–129

    Google Scholar 

  4. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurements with the Folin phenol reagent. J Biol Chem 193:265–275

    PubMed  Google Scholar 

  5. Nagayama J, Kuroki H, Masuda Y, Kuratsune M (1983) A comparative study of polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin on aryl hydrocarbon hydroxylase inducing potency in rats. Arch Toxicol 53:177–184

    PubMed  Google Scholar 

  6. Nagayama J, Kiyohara C, Masuda Y, Kuratsune M (1985a) Inducing potency of aryl hydrocarbon hydroxylase in human lymphoblastoid cells and mice by polychlorinated dibenzofuran congeners. Environ Health Perspec 59:101–112

    Google Scholar 

  7. Nagayama J, Kiyohara C, Masuda Y, Kuratsune M (1985b) Genetically mediated induction of aryl hydrocarbon hydroxylase activity in human lymphoblastoid cells by polychlorinated dibenzofuran isomers and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch Toxicol 56:230–235

    PubMed  Google Scholar 

  8. Nebert DW, Gelboin HV (1968a) Substrate-inducible microsomal aryl hydrocarbon hydroxylase in mammalian cell culture.1. Assay and properties of induced enzyme. J Biol Chem 243:6242–6249

    PubMed  Google Scholar 

  9. Nebert DW, Gelboin HV (1968b) Substrate-inducible microsomal aryl hydrocarbon hydroxylase in mammalian cell.2. Cellular responses during enzyme induction. J Biol Chem 243:6250–6251

    PubMed  Google Scholar 

  10. Nebert DW, Gelboin HV (1969) The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. Arch Biochem Biophys 134:76–89

    PubMed  Google Scholar 

  11. Nebert DW, Benedict WF, Kouri RE (1974) Aromatic hydrocarbon-produced tumorigenesis and the genetic difference in aryl hydrocarbon hydroxylase. In: Tso PO, DiPaolo JA (eds) Chemical carcinogenesis, Part A, Marcell Dekker Inc., New York, pp271–288.

    Google Scholar 

  12. Nebert DW, Robinson JR, Niwa A, Kumaki K, Poland A (1975) Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J Cell Physiol 85:393–414

    PubMed  Google Scholar 

  13. Nebert DW, Jensen NM (1979) The Ah locus: genetic regulation of the metabolism of carcinoges, drugs, and other environmental chemicals by cytochrome P-450-mediated monooxygenase. Crit Rev Biochem, CRC Press, Cleveland

    Google Scholar 

  14. Poland A, Glover E, Robinson JR, Nebert DW (1974) Genetic expression of aryl hydrocarbon hydroxylase activity. J Biol Chem 249:5599–5606

    PubMed  Google Scholar 

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Correspondence to Chikako Kiyohara.

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Kiyohara, C., Mohri, N., Nagayama, J. et al. Strain- and organ-dependent differences in induction of aryl hydrocarbon hydroxylase activity by 3-methylcholanthrene. Bull. Environ. Contam. Toxicol. 43, 185–191 (1989). https://doi.org/10.1007/BF01701746

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Keywords

  • Waste Water
  • Hydrocarbon
  • Water Management
  • Water Pollution
  • Hydroxylase Activity