Summary
A patient with a myelodysplastic syndrome (MDS) and reticulocytosis of >50% in the absence of a correspondingly increased erythrocyte turnover is reported. Evaluation of the kinetics of erythrocyte turnover revealed a decreased erythrocyte life span of 44 days. From these data a prolongation of the reticulocyte maturation time to >20 days can be concluded. The patient's erythrocytes lacked the increase of mean corpuscular volume and a significant increase of erythrocyte enzymes that would be expected in marked reticulocytosis. This finding suggests that the reticulocytes represented not newly formed red blood cells, but “pseudoreticulocytes”, i.e., mature erythrocytes that retained their substantia reticulofilamentosa.
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Cazzola M, Barosi G, Berzuini C, Dacco M, Orlandi E, Steffanelli M, Ascari E (1982) Quantitative evaluation of erythropoietic activity in dysmyelopoietic syndromes. Br J Haematol 50:55–62
Donohue M, Motulsky AG, Giblett ER, Pirzio-Biroli G, Viranuvatti V, Finch CA (1955) The use of Cr-51 as red cell tag. Br J Haematol 1:249–254
Dreyfus B, Sultan C, Rochant H, Salmon C, Mannoni P, Cartron JP, Boivin P, Galand C (1969) Anomalies of blood group antigens and erythrocyte enzymes in two types of chronic refactory anaemia. Br J Haematol 16:303–312
Heilmeyer L, Westhäuser R (1932) Reifungsstadien an überlebenden Retikulozyten in vitro und ihre Bedeutung für die Schätzung der täglichen Hämoglobinproduktion in vivo. Z Klin Med 121:361–379
Heimpel H (1968) Erythropoese und Erythrozytenumsatz. In: Heilmeyer L (ed) Handbuch der inneren Medizin. Springer, Berlin Heidelberg New York, pp 514–584
Linman JW, Saarni MI (1974) The preleukemic syndrome. Semin Hematol 11:93–100
Lofters WS, Ali MAM, Pineo GF (1978) Preleukemia and reticulocytosis: a case report with in vitro evidence for abnormal reticulocyte maturation. Scand J Haematol 20:417–422
Repka T, Rank BH (1989) Reticulocytosis: defective reticulin degradation, a case report. Prog Clin Biol Res 319:291–302
Rochant H, Dreyfus B, Bouguerra M, Tont-Hat H (1972) Refractory animias, preleukimic conditions and fetal erythropoiesis. Blood 39:721–726
Tulliez M, Testa U, Rochant H, Henri W, Vainchenker W, Touboul J, Breton-Gorius J, Dreyfus B (1982) Reticulocytosis, hypochromia, and microcytosis: an unusual presentation of the preleukemic syndrome. Blood 59:293–299
Wintrobe MM (1981) Clinical hematology. Lee and Febiger, Philadelphia
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Hertenstein, B., Kurrle, E., Redenbacher, M. et al. Pseudoreticulocytosis in a patient with myelodysplasia. Ann Hematol 67, 127–128 (1993). https://doi.org/10.1007/BF01701735
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DOI: https://doi.org/10.1007/BF01701735