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Annals of Hematology

, Volume 67, Issue 3, pp 111–114 | Cite as

Frozen vs. nonfrozen bone marrow for autologous transplantation in lymphomas: A report from the Spanish GEL/TAMO Cooperative Group

  • J. Sierra
  • E. Conde
  • A. Iriondo
  • S. Brunet
  • J. Marín
  • J. Pérez de Oteiza
  • D. Caballero
  • F. Martínez
  • A. León
  • J. García-Conde
  • F. Hernández-Navarro
  • A. Domingo
  • D. Carrera
  • J. C. Reverter
  • C. Richard
  • J. Zuazu
  • J. Baro
  • J. Rifón
  • C. Solano
  • J. Díaz-Mediavilla
  • C. Rozman
  • E. Montserrat
  • Spanish Cooperative Group GEL/TAMO
Original Article

Summary

To investigate the impact of frozen and nonfrozen bone marrow on engraftment kinetics and disease outcome, 94 patients with non-Hodgkin's lymphoma (NHL) autografted with frozen marrow (F group) were retrospectively compared with 38 who received marrow stored at 4° C or 10° C (NF group). The major end points of this study were time to hematopoietic recovery and early toxicity; disease response, diseasefree survival (DFS), and relapse rate were also analyzed. Upon comparison of the NF and F groups, no significant differences were found in the period of time required to achieve a granulocyte count higher than 0.5×109/l (20 and 22 days, respectively,p=0.47) or a platelet count higher than 20×109/l (28 and 27 days, respectively,p=0.54). In addition, both groups behaved similarly in respect to toxic death (NF group 13%, F group 22%,p=0.36), response rate (complete remission rate 78% in both groups), DFS (NF group 48%, F group 49%,p=0.66), and relapse rate (NF group 30, F group 19%,p=0.37). This study confirms that nonfrozen bone marrow is useful to support patients with NHL treated with myeloablative therapies.

Key words

Nonfrozen Marrow Autologous Transplantation Lymphomas 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • J. Sierra
    • 2
  • E. Conde
    • 1
  • A. Iriondo
    • 1
  • S. Brunet
    • 3
  • J. Marín
    • 5
  • J. Pérez de Oteiza
    • 4
  • D. Caballero
    • 6
  • F. Martínez
    • 7
  • A. León
    • 8
  • J. García-Conde
    • 4
    • 9
  • F. Hernández-Navarro
    • 10
  • A. Domingo
    • 3
  • D. Carrera
    • 11
  • J. C. Reverter
  • C. Richard
    • 1
  • J. Zuazu
    • 12
  • J. Baro
    • 1
  • J. Rifón
    • 13
  • C. Solano
    • 9
  • J. Díaz-Mediavilla
    • 14
  • C. Rozman
    • 2
  • E. Montserrat
    • 2
  • Spanish Cooperative Group GEL/TAMO
    • 15
  1. 1.Hospital Marqués de ValdecillaSantander
  2. 2.Hospital ClínicBarcelona
  3. 3.Hospital Santa Creu i Sant PauBarcelona
  4. 4.Hospital Ramón y CajalMadrid
  5. 5.Hospital Nuestra Señora de AranzazuSan Sebastián
  6. 6.Hospital ClinicoSalamanca
  7. 7.Hospital Reina SofíaCórdoba
  8. 8.Hospital de Jerez de la FronteraCádiz
  9. 9.Hospital ClínicoValencia
  10. 10.Hospital Nuestra Señora del PinoLas Palmas de Gran Canaria
  11. 11.Hospital Nuestra Señora de CovadongaOviedo
  12. 12.Hospital Vall d'HebrónBarcelona
  13. 13.Clínica Universitaria de NavarraPamplona
  14. 14.Hospital ClínicoMadrid
  15. 15.Hospital 12 de OctubreMadrid

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