Skip to main content

Effect of reticuloendothelial system blockade on the biotransformation of methyl mercury in the rat

This is a preview of subscription content, access via your institution.



methyl mercury




colloidal carbon


trypan blue


colloidal iron


reticuloendothelial system


  1. Biozzi G, Benacerraf B, Halpern BN (1953) Quantitative study of the granulopectic activity of the reticulo-endothelial system. Brit J Exp Path 34:441–457

    Google Scholar 

  2. Brouwer A, Knook DL (1983) The reticuloendothelial system and aging: A review. Mech Age Dev 21:205–228

    Google Scholar 

  3. Fisher S (1966) Stimulation of splenic antigen uptake and of antibody response in mice by India ink or other ‘blockading’ agents. Immunology 11:127–136

    Google Scholar 

  4. Hirokawa K, Hayashi Y (1980) Acute methyl mercury intoxication in mice: Effect on the immune system. Acta Pathol Jpn 30:23–32

    Google Scholar 

  5. Konishi T, Takahashi H (1983) Direct determination of inorganic mercury in biological materials after alkali digestion and amalgamation. Analyst 108:827–834

    Google Scholar 

  6. Norseth T, Clarkson, TW (1970) Studies on the biotransformation of203Hg-labeled methyl mercury chloride in rats. Arch Environ Health 21:717–727

    Google Scholar 

  7. Norseth T (1971) Biotransformation of methyl mercuric salts in germ free rats. Acta Pharmacol Toxicol 30:172–176

    Google Scholar 

  8. Rodier PM, Kates B (1988) Histological localization of methylmercury in mouse brain and kidney by emulsion autoradiography of203Hg. Toxicol Appl Pharmacol 92:224–234

    Google Scholar 

  9. Rowland IR, Davies MJ, Evans JG (1980) Tissue content of mercury in rats given methylmercuric chloride orally: Influence of intestinal flora. Arch Environ Health 35:155–160

    Google Scholar 

  10. Rowland IR, Robinson RD, Doherty RA (1984) Effects of diet on mercury metabolism and excretion in mice given methylmercury: Role of gut flora. Arch Environ Health 39:401–408

    Google Scholar 

  11. Seko Y, Miura T, Takahashi M, Koyama T (1981) Methyl mercury decomposition in mice treated with antibiotics. Acta Pharmacol Toxicol 49:259–265

    Google Scholar 

  12. Souhami RL, Bradfield (1974) The recovery of hepatic phagocytosis after blockade of Kupper cells. J Reticuloend Soc 16:75–86

    Google Scholar 

  13. Suda I, Takahashi H (1986) Enhanced and inhibited biotransformation of methyl mercury in the rat spleen. Toxicol Appl Pharmacol 82:45–52

    Google Scholar 

  14. Suda I, Eto K, Tokunaga H, Furusawa R, Suetomi K, Takahashi H (1989) Different histochemical findings in the brain produced by mercuric chloride and methyl mercury chloride in rats. Neurotoxicol 10:113–126

    Google Scholar 

  15. Takahashi H, Suda I (1986) Metabolic fate of methylmercury in animals. In: Tsubaki T, Takahashi H (ed) Recent advances in Minamata disease studies, Kodansha, Tokyo, pp 135–150

    Google Scholar 

  16. Takahashi H, Wada S, Suda I, Totoki S, Ohota J (1988) Toxicological and metabolic aspects of organic mercury poisoning. J UOEH 10:117–126

    Google Scholar 

  17. Yoshikai Y, Miake S, Matsumoto T, Nomoto K, Takeda K (1979) Effect of stimulation and blockade of mononuclear phagocyte system on the delayed footpad reaction to SRBC in mice. Immunol 38:577–583.

    Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Ikuo Suda.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Suda, I., Takahashi, H. Effect of reticuloendothelial system blockade on the biotransformation of methyl mercury in the rat. Bull. Environ. Contam. Toxicol. 44, 609–615 (1990).

Download citation


  • Methyl
  • Waste Water
  • Mercury
  • Water Management
  • Water Pollution