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Immunological differentiation between tickborne encephalitis with and without concomitant neuroborreliosis

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Abstract

Cerebrospinal fluid lymphocyte subsets in patients with tickborne encephalitis (TBE) and in patients with TBE with concomitant neuroborreliosis (double infection) were analysed by flow cytometry. In the TBE group, higher percentages of CD4+DR+ T cells (p = 0.02) and CD25+ T cells (p = 0.0002) were observed, while in the group with double infection, higher percentages of CD19+ cells (p = 0.007), CD8+DR- T cells (p = 0.04), and CD3+CD71 + T cells (p = 0.0002) were found. It was concluded that several differences in immune cell parameters are present between the two groups of patients. Three variables (CD19+ cells, CD3+CD25+ T cells, CD3+CD71 + T cells) were included in the logistic regression model for calculation of probability for double infection. Flow cytometric characterisation of lymphocyte subsets in CSF can further substantiate the diagnosis of concomitant neuroborreliosis in patients with TBE.

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Authors and Affiliations

  1. Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525, Ljubljana, Slovenia

    J. Tomažič, F. Strle, J. Cimperman & M. Matičič

  2. Department of Immunology, Institute of Microbiology, University Ljubljana, Vrazov trg 2, 1525, Ljubljana, Slovenia

    A. Ihan

  3. Department of Biomedical Informatics, Faculty of Medicine, University Ljubljana, Vrazov trg 2, 1525, Ljubljana, Slovenia

    J. Stare

  4. Department of Medical Oncology, Institute of Oncology, Zaloska 2, 1525, Ljubljana, Slovenia

    B. Zakotnik

Authors
  1. J. Tomažič
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  2. A. Ihan
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  3. F. Strle
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  5. J. Stare
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  6. M. Matičič
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  7. B. Zakotnik
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Tomažič, J., Ihan, A., Strle, F. et al. Immunological differentiation between tickborne encephalitis with and without concomitant neuroborreliosis. Eur. J. Clin. Microbiol. Infect. Dis. 16, 920–923 (1997). https://doi.org/10.1007/BF01700560

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