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Risk of human immunodeficiency virus (HIV) transmission by anti-HIV-negative blood components in Germany and Austria

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Abstract

In order to estimate the residual risk of transfusion-transmitted HIV infection we have analyzed the data from two transfusion centers in Austria (Vienna) and Germany (Göttingen) from 1985 to 1994. In Vienna, an incidence of 1∶42000 positive anti-HIV tests in repeat donors and a prevalence of 1∶7000 in first-time donors were found in 1993. In Göttingen, the indicence was 1∶67000 and the prevalence 1∶7900 from 1985 to 1993. Based on a mathematical model which takes (a) the window period and (b) the false-negative rate of anti-HIV tests, as well as (c) human and operational errors into consideration, we have calculated the residual risk of HIV infection. The residual risk (third generation anti-HIV test) was found to be 1∶520000 (95% confidence interval 1∶1340000-1∶210000), and 1∶900000 (95% confidence interval 1∶2340000-1∶380000) for Vienna and Göttingen, respectively, in 1993. Look-back studies from 1985 till 1994 revealed transfusion-transmitted HIV infections in three recipients (for 1.9 million donations in Vienna) and one recipient (for 160000 donations in Göttingen) of blood components. Based on our model, as well as on prevalence and incidence rates of HIV infection, it is also possible to predict the efficacy of additional measures introduced to further decrease the risk of transfusion-transmitted HIV infection through blood components.

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Authors and Affiliations

  1. Department of Transfusion Medicine, University of Göttingen, Robert-Koch Strasse 40, D-37075, Göttingen, Germany

    G. Simson, H. Fabritz, J. Riggert, H. Neumeyer & M. Köhler

  2. University Clinic for Blood Group Serology and Transfusion Medicine, University of Vienna and Austrian Red Cross Blood Donation Center, Währinger Gürtel 18–20, A-1090, Vienna, Austria

    D. W. M. Schwartz, K. Baumgarten & W. R. Mayr

Authors
  1. D. W. M. Schwartz
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  2. G. Simson
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  3. K. Baumgarten
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  4. H. Fabritz
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  5. J. Riggert
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  6. H. Neumeyer
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  7. W. R. Mayr
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  8. M. Köhler
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Schwartz, D.W.M., Simson, G., Baumgarten, K. et al. Risk of human immunodeficiency virus (HIV) transmission by anti-HIV-negative blood components in Germany and Austria. Ann Hematol 70, 209–213 (1995). https://doi.org/10.1007/BF01700377

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  • DOI: https://doi.org/10.1007/BF01700377

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