Skip to main content

Advertisement

SpringerLink
Log in

Mycobacterium celatum infection in two HIV-infected patients treated prophylactically with rifabutin

  • Note
  • Published:
European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

Mycobacterium celatum is a recently described slow-growing species. It was identified on the basis of genomic sequencing that differentiates three types. The present report describes two cases ofMycobacterium celatum type I infection in patients with AIDS. Both patients had CD4+ lymphocyte counts of <10/mm3, were receiving rifabutin prophylaxis, and had attended the same treatment units. The minimum inhibitory concentration of rifabutin for both strains was 8 mg/l, which may account for the failure of prophylaxis. As all type 1 strains have the same pulsedfield gel electrophoresis pattern, nosocomial transmission or acquisition from a common source could not be ruled out.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Butler WR, Steven P, O'Connor SP, Yarkus MA, Smithwick RW, Plikaytis BB, Moss CW, Floyd MM, Woodley CL, Kilburn JO, Vadney FS, Gross WM:Mycobacterium celatum sp. nov. International Journal of Systematic Bacteriology (1993) 43:539–548.

    PubMed  Google Scholar 

  2. Butler WR, O'Connor SP, Yarkus MA, Gross WM: Cross reactivity of genetic probe for detection ofMycobacterium tuberculosis with newly described speciesMycobacterium celatum. Journal of Clinical Microbiology (1994) 32:536–538.

    PubMed  Google Scholar 

  3. Bull TJ, Shanson DC, Archard LC, Yates MD, Hamid ME, Minnikin DE: A new group (type 3) ofMycobacterium celatum isolated from AIDS patients in the London area. International Journal of Systematic Bacteriology (1995) 45:861–862.

    PubMed  Google Scholar 

  4. Piersimoni C, Tortoli E, De Sio G: Disseminated infection due toMycobacterium celatum in patient with AIDS. Lancet (1994) 344:332.

    Google Scholar 

  5. Haase G, Skopnik H, Batge S, Bottger EC: Cervical lymphadenitis caused byMycobacterium celatum. Lancet (1994) 344:1020–1021.

    Google Scholar 

  6. Tortoli E, Piersimoni C, Bacosi D, Bartoloni A, Betti F, Bono L, Burrini C, De Sio G, Lacchini C, Mantella A, Orsi PG, Penati V, Simonetti MT, Bottger EC: Isolation of the newly described speciesMycobacterium celatum from AIDS patients. Journal of Clinical Microbiology (1995) 33:137–140.

    PubMed  Google Scholar 

  7. Dahl DM, Klein D, Morgentaler A: Penile mass caused by the newly described organismMycobacterium celatum. Urology (1996) 47:266–268.

    PubMed  Google Scholar 

  8. Piersimoni C, Tortoli E, De Lalla F, Nista D, Donato D, Bornigia S, De Sio G: Isolation ofMycobacterium celatum from patients infected with human immunodeficiency virus. Clinical Infectious Diseases (1997) 24:144–147.

    PubMed  Google Scholar 

  9. Zurawski CA, Cage GD, Rimland D, Blumberg HM: Pneumonia and bacteremia due toMycobacterium celatum masquerading asMycobacterium xenopi in patients with AIDS: an underdiagnosed problem? Clinical Infectious Diseases (1997) 24:140–143.

    PubMed  Google Scholar 

  10. David H, Lévy-Frébault V, Thorel MF: Méthodes de laboratoire pour mycobactériologie clinique. Institut Pasteur, Paris (1989) pp. 463–474.

    Google Scholar 

  11. Kirshner P, Springer B, Vogel U, Meier A, Wrede A, Kiekenbeck M, Bange FC, Bottger EC: Genotypic identification of mycobacteria by nucleic acid sequence determination: report of a 2-year experience in a clinical laboratory. Journal of Clinical Microbiology (1993) 31:2882–2889.

    PubMed  Google Scholar 

  12. Picardeau M, Varnerot A, Rauzier J, Gicquel B, Vincent V:Mycobacterium xenopi IS1395, a novel insertion sequence expanding the IS256 family. Microbiology (1996) 142:2453–2461.

    PubMed  Google Scholar 

  13. Rastogi N, Bauriaud RM, Bourgoin A, Carbonelle B, Chippaux C, Gevaudan MJ, Seng Goh K, Moinard D, Roos P: French multicenter study involving eight test sites for radiometric determination of 10 antimicrobial agents againstMycobacterium avium complex. Antimicrobial Agents and Chemotherapy (1995) 39:638–644.

    PubMed  Google Scholar 

  14. Maslo C, Buré-Rossier A, Girard PM, Gholizadeh Y, Lebrette MG, Rozenbaum W: Clinical and bacteriologic impact of rifabutin prophylaxis forMycobacterium avium complex infection in patients with human immunodeficiency virus infection. Clinical Infectious Diseases (1997) 24:344–349.

    PubMed  Google Scholar 

  15. Picardeau M, Bull TJ, Prod'hom G, Pozniak AL, Shanson DC, Vincent V: Comparison of a new insertion element, IS1407, with established molecular markers for the characterization ofMycobacterium celatum. International Journal of Systematic Bacteriology (1997) 47:640–644.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Microbiologie, Hôpital Rothschild, 33 Boulevard de Picpus, F-75012, Paris, France

    Y. Gholizadeh, B. Salauze, H. Badaoui & A. Buré-Rossier

  2. Centre National de Référence des Mycobactéries, Institut Pasteur, 25 Rue du Docteur Roux, F-75015, Paris, France

    A. Varnerot & V. Vincent

  3. Service des Maladies Infectieuses et Tropicales, Hôpital Rothschild, 33 Boulevard de Picpus, F-75012, Paris, France

    C. Maslo

Authors
  1. Y. Gholizadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Varnerot
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Maslo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. Salauze
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Badaoui
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. Vincent
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. Buré-Rossier
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gholizadeh, Y., Varnerot, A., Maslo, C. et al. Mycobacterium celatum infection in two HIV-infected patients treated prophylactically with rifabutin. Eur. J. Clin. Microbiol. Infect. Dis. 17, 278–281 (1998). https://doi.org/10.1007/BF01699987

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01699987

Keywords

Search

Navigation