Abstract
Treatment with aminophylline, according to the nomogram published by Jusko and coworkers, was monitored in 13 patients suffering from acute exacerbations of COPD. After 24 h of therapy, the clinical state, the pO2 and the pCO2 values were markedly improved. Theophylline plasma concentrations were maintained within the therapeutic range. A slight but noticeable increase of drug serum levels during therapy could be related to changes in the arterial pH; the implications of this finding are discussed.
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References
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Calandre, E.P., Perez de la Cruz, A.J., Morales, A.M. et al. Monitoring aminophylline therapy using Jusko's dosage guidelines. Intensive Care Med 9, 79–81 (1983). https://doi.org/10.1007/BF01699261
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DOI: https://doi.org/10.1007/BF01699261