References
Allen JR, Barsotti DA, Lambrecht LK, nvan Miller JP (1979) Reproductive effects of halogenated aromatic hydrocarbons on nonhuman primates. Ann. N.Y. Acad. Sci. 320:419–425
Biessmann A (1981) Accumulation of polychlorinated biphenyls in steroidogenic tissue of gonads and adrenals in Japanese Quail. Arch. Environ. Contam. Toxicol. 10:653–662.
Biessmann A (1982) Effects of PCBs on gonads, sex hormone balance and reproduction processes of Japanese QuailCoturnix Coturnix Japonica after ingestion during sexual maturation. Environ. Poll. (series A) 27:15–30
Bitman J, Cecil HC (1970) Estrogenic activity of DDT analogs and polychlorinated biphenyls. J. Agr. Food Chem. 18:1108–1112
Brandt I (1977) Tissue localization of polychlorinated biphenyls. Chemical structure related to pattern of distribution. Acta Pharmacol. Toxicol. 40 (suppl. II):1–108 (thesis)
Brunström B, Darnerud PO (1983) Toxicity and distribution in chick embryos of 3,3′,4,4′-tetrachlorobiphenyl injected into the eggs. Toxicology 27:103–110
Conney AH, Kuntzman R (1971) Metabolism of normal body constituents by drug-metabolizing enzymes in liver microsomes. In: Brodie BB, Gillette J (eds) Concepts in Biochemical Pharmacology, Handbook of Experimental Pharmacology Series, vol 28. Springer-Verlag, New York, pp 401–405
Conney AH, Levin W, Jacobson M, Kuntzman R (1973) Effects of drugs and environmental chemicals on steroid metabolism. Clin. Pharmacol. Ther. 14:727–741
de V. Weir JB (1960) Standardized t. Nature 185:558
Freeman HC, Sangalang GB (1977) A study of the effects of methyl mercury, cadmium, arsenic, selenium and a PCB (Aroclor 1254) on adrenal and testicular steroidogenesesin vitro, by the Gray SealHalichoerus Grypus. Arch. Environ. Contam. Toxicol. 5:369–383
Fuller GB, Knauf V, Müller W, Hobson WC (1980) PCB augments LH-induced progesterone synthesis. Bull. Environ. Contam. Toxicol. 25:65–68
Hook GER, Orton TC, Moore JA, Lucier GW (1975) 2,3,7,8-Tetrachlo-rodibenzo-p-dioxin-induced changes in the hydroxylation of biphenyl by rat liver microsomes. Biochem. Pharmacol. 24:335–340
Jensen S (1966) Report of a new chemical hazard. New Scientist 32:612
Johansson B (1987) Lack of effects of polychlorinated biphenyls on testosterone synthesis in mice. Pharmacol. Toxicol. 61:220–223
Moore RW, Potter CL, Theobald HM, Robinson JA, Peterson RE (1985) Androgenic deficiency in male rats treated with 2,3,7,8-tetra-chlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 79:99–111
Nowicki HG, Norman AW (1972) Enhanced hepatic metabolism of testosterone, 4-androstene-3, 17-dione, and estradiol-17β in chickens pretreated with DDT or PCB. Steroids 19:85–99
Örberg J, Kihlström JE (1973) Effects of long-term feeding of polychlorinated biphenyls (PCB, Clophen A60) on the length of the oestrus cycle and on the frequency of implanted ova in the mouse. Environ. Res. 6:176–179
Örberg J, Lundberg C (1974) Some effects of DDT and PCB on the hormonal system in the male mouse. Environ. Physiol. Biochem. 4:116–120
Pont A, Williams PL, Azhar S, Reitz RE, Bochra C, Smith ER, Stevens DA (1982) Ketoconazole blocks testosterone synthesis. Arch. Intern. Med. 142:2137–2140
Rogers CG, Heroux-Metcalf C, Iverson F (1983)In vitro cytotoxicity of polychlorinated biphenyls (Aroclor 1016, 1242, 1254 and 1260) and their effect on phospholipid and neutral lipid composition of Chinese hamster ovary (CHO-K1) cells. Toxicology 26:113–124
Sager DB (1983) Effect of postnatal exposure to polychlorinated biphenyls on adult male reproductive function. Environ. Res. 31:76–94
Tofilon PJ, Piper WN (1982) 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated depression of rat testicular heme synthesis and microsomal cytochrome P-450. Biochem. Pharmacol. 31:3663–3666
Van Damme MP, Robertson DM, Diczfalusy E (1974) An improvedin vitro bioassay method for measuring luteinizing hormone (LH) activity using mouse Leydig cell preparations. Acta Endocr. 77:655–671
Yoshimura H, Yoshihara S, Ozawa N, Miki M (1979) Possible correlation between induction modes of hepatic enzymes by PCBs and their toxicity in rats. Ann. N.Y. Acad Sci. 320:179–192
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Johansson, B. Effects of polychlorinated biphenyls (PCBs) onin vitro biosynthesis of testosterone and cell viability in mouse leydig cells. Bull. Environ. Contam. Toxicol. 42, 9–14 (1989). https://doi.org/10.1007/BF01699197
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DOI: https://doi.org/10.1007/BF01699197