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Translocation (14; 18) and (8; 22) in three patients with acute leukemia/lymphoma following centrocytic/centroblastic non-Hodgkin's lymphoma

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Summary

Three patients with centrocytic/centroblastic lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.

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Authors and Affiliations

  1. Department of Oncology and Hematology, University Hospital Eppendorf, Martinistrasse 52, W-2000, Hamburg 20, FRG

    W. Fiedler, H. J. Weh, W. Zeller & D. K. Hossfeld

  2. Department of Human Genetics, Medical University, Lübeck, Federal Republic of Germany

    C. Fonatsch

  3. Department of Molecular Genetics, Unity 301, I.N.S.E.R.M., Paris, France

    J. Hillion & C. Larsen

  4. Medical University Clinic, Internal Medicine A, Münster, Federal Republic of Germany

    B. Wörmann

Authors
  1. W. Fiedler
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  2. H. J. Weh
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  3. W. Zeller
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  4. C. Fonatsch
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  5. J. Hillion
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  6. C. Larsen
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  7. B. Wörmann
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  8. D. K. Hossfeld
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Additional information

This study was supported by theHamburger Krebsgesellschaft and by grants Fi 389/2-2 and Fo 91/11-3 from theDeutsche Forschungsgemeinschaft

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Fiedler, W., Weh, H.J., Zeller, W. et al. Translocation (14; 18) and (8; 22) in three patients with acute leukemia/lymphoma following centrocytic/centroblastic non-Hodgkin's lymphoma. Ann Hematol 63, 282–287 (1991). https://doi.org/10.1007/BF01698379

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  • DOI: https://doi.org/10.1007/BF01698379

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