Summary
In the attempt to evaluate the role of Autologous and Allogeneic Bone Marrow Transplantation, we have retrospectively analyzed 159 patients with Acute Myeloid Leukemia in first complete remission treated in our Unit, most of whom were referred from other Institutions. High-dose therapy was uniform and consisted of cyclophosphamide 60 mg/kg/d on two consecutive days and TBI in a single dose (10 Gy) for ABMT patients and in fractionated doses (3.3 Gy × 3 days) for BMT patients. Eight years actuarial survival was similar in two groups (52% for BMT and 49% for ABMT). The actuarial risk of relapse for BMT and ABMT was 29% and 43%, respectively. Considering that none of ABMT patients was “purged” with in vitro technique, this review seems to confirm the importance of “in vivo” purging with postremission intensification, immediately before the harvesting. Of course, more patients and a longer follow-up are needed to drow final conclusions.
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Burnett AK, Goldstone AH, Hann IM, Stevens RF, Ress JKH, Wheatley K, Gray RG (1990) Evaluation of autologous bone marrow transplantation in acute myeloid leukemia: a progress report on the MRC tenth AML trial. ABMT, Omaha, pp 3–7
Carella AM, Gaozza E, Piatti G, Nati S, Pungolino E, Santini G, Giordano D, Cerri R, Risso M, Rossi E, Spriano M, Congiu A, Carlier P, Raffo MR, Damasio E, Bacigalupo A, Marmont A (1990) A new combination of idarubicin, etoposide and cytarabine in untreated acute non-lymphoblastic leukemia. Leukemia Lymphoma 2: 317–322
Carella AM, Nati S, Carlier P, Pierluigi D, Giordano D, Congiu A, Santini G, Scarpati D, Barra S, Corvo R, Vitale V, Raffo MR, Cerri R, Risso M, Spriano M, Vimercati R, Pungolino E, Bacigalupo A, Damasio E (1991) Autologous unpurged bone marrow transplantation for acute non-lymphoblastic leukemia in first remission. Leukemia Lymphoma 5: 43–47
Cassileth PA, Andersen J, Lazarus HM, Kaizer H, Bloom E, Elfenbein GJ, Santos GW, Bennett JM, Colvin OM, Oken MM (1990) Autologous bone marrow transplantation in acute myeloid leukemia in first remission: an Eastern Cooperative Oncology Group pilot study. ABMT, Omaha, pp 37–41
Gorin NC, Aegeder P, Auvert B, Meloni G, Goldstone AH, Korbling M, Herve' P, Burnett A, Maraninchi D, Carella A, Verdonck LF, Lowenberg R, De Planque, Helbig W, Reiffers J, Porcellini A, Rizzoli V, Sonillet G, Alessandrino EP, Franklin IM, Goldman JM (1990) Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: a European survey of the role of marrow purging. Blood 75: 1606–1614
Gorin NC, Lobopin M, Meloni G, Korbling M, Carella AM, Herve' P, Burnett A, Rizzoli V, Alessandrino PE, Bjorkstrand B, Ferrant A, Lowenberg B, Coser P, Simonsson B, Helbing W, Brunet Maun S, Verdonck LF, Iriondo A, Polli E, Colombat P, Franklin IM, Souillet G, Willemze R (1991) Autologous bone marrow transplantation for acute myeloblastic leukemia in Europe: further evidence of the role of marrow purging by mafosfamide. Leukemia 5: 896–904
Korbling M, Hunstein W, Fliedner TM (1989) Disease-free survival after autologous bone marrow transplantation in patients with acute myelogenous leukemia. Blood 74: 1898–1904
Meloni G, De Fabritiis P, Carella AM, Mangoni L, Porcellini A, Marmont AM, Mandelli F (1990) Autologous BMT in patients with AML in first complete remission. Results of two different conditioning regimens after the same induction and consolidation therapy. Bone Marrow Transplant 5: 29–32
Oshimi K, Oshimi Y, Akutsu M (1986) Cytotoxicity of interleukin 2-activated lymphocytes for leukemia and lymphoma cells. Blood 68: 938–948
Reiffers J, Gaspard MH, Maraninchi D, Michallet M, Marit G, Stoppa AM, Corront B, David B, Gastaut JA, Sotto JJ, Broustet A, Carcassone Y, Hollard D (1989) Comparison of allogeneic or autologous bone marrow transplantation and chemotherapy in patients with acute myeloid leukemia in first remission: a prospective controlled trial. Br J Haematol 72: 57–63
Santos GW (1989) Marrow transplantation in acute nonlymphocytic leukemia. Blood 74: 901–908.
Yeager AM, Kaizer H, Santos GW, Saral R, Colvin OM, Stuart RK, Braine HG, Burke PJ, Ambinder RF, Burns WH, Fuller DJ, Davis JM, Karp JE, May WS, Rowley SD, Sensenbrenner LL, Vogelsang GB, Wingard JR (1986) Autologous bone marrow transplantation in patients with acute nonlymphocytic leukemia: a phase-II study of ex vivo marrow treatment with 4-hydroperoxycyclophosphamide. N Engl J Med 315: 141–147
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Carella, A.M., Frassoni, F., van Lint, M.T. et al. Autologous and allogeneic bone marrow transplantation in acute myeloid leukemia in first complete remission: an update of the Genoa experience with 159 patients. Ann Hematol 64, 128–131 (1992). https://doi.org/10.1007/BF01697399
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DOI: https://doi.org/10.1007/BF01697399