Skip to main content
Log in

Human cancer and gene therapy

  • Review Article
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Acsadi G, Dickson G, Love DR, Jani A, Walsh FS, Gurusinghe A, Wolf JA, Davies KE (1991) Human dystrophin expression in MDX mice after intramuscular injection of DNA construct. Nature 332:815–818

    Google Scholar 

  2. Anderson WF (1992) Human gene therapy. Science 256:808–813

    PubMed  Google Scholar 

  3. Anderson WF, Killos L, Sanders-Haigh L, Kretschmer PJ, Diacumakos EG (1980) Replication and expression of thymidine kinase and human globin genes microinjected into mouse fibroblasts. Proc Natl Acad Sci USA 77:5399–5403

    PubMed  Google Scholar 

  4. Berglund P, Sjoberg M, Garoff H, et al. (1993) Semliki forest virus expression system: production of conditionally infectious recombinant particles. Biotechnology 11:916–920

    PubMed  Google Scholar 

  5. Clinical Protocols (1994) Cancer Gene Therapy 1:73–78

    Google Scholar 

  6. Cohen JS (1992) Selective anti-gene therapy for cancer: principles and prospects. Tohoku J Exp Med 168:351–359

    PubMed  Google Scholar 

  7. Cooney EL, McElrath MJ, Corey Lk et al (1993) Enhanced immunity to human immunodeficiency virus (HIV) envelope elicited by a combined vaccine regimen consisting of priming with a vaccinia recombinant expressing HIV envelope and boosting with gp160 protein. Proc Natl Acad Sci USA 90:1882–1886

    PubMed  Google Scholar 

  8. Cornetta K (1992) Safety aspects of gene therapy. Br J Haematol 80:421–426

    PubMed  Google Scholar 

  9. Cournoyer D, Caskey CT (1993) Gene therapy of the immune system. Annu Rev Immunol 11:297–329

    PubMed  Google Scholar 

  10. Culver K et al. (1994) Clinical protocol: gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system. Hum Gene Ther 5:343–377

    PubMed  Google Scholar 

  11. Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM (1992) In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256:1550–1552

    PubMed  Google Scholar 

  12. Deisseroth AB (1994) Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic stem cells for chemoprotection during the therapy of ovarian cancer: a pilot trial. Hum Gene Ther (in press)

  13. DeVita V, Hellman S, Rosenberg SA (eds) (1991) Biologic therapy of cancer. Lippincott, Philadelphia

    Google Scholar 

  14. Donahue RE, Kessler SW, Bodine D et al. (1992) Helper virus-induced T-cell lymphoma in nonhuman primates after retroviral-mediated gene transfer. J Exp Med 176:1125–1135

    PubMed  Google Scholar 

  15. Evans DJ, McKeating J, Meredith JM (1989) An engineered poliovirus chimaera elicits broadly reactive HIV-1 neutralizing antibodies. Nature 339:385–388

    PubMed  Google Scholar 

  16. Fearon ER, Pardoll DM, Itaya T et al. (1992) Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell 60:397–403

    Google Scholar 

  17. Federal Drug Administration (1990) FDA draft points to consider on human somatic cell therapy and gene therapy. Hum Gene Ther 2:251–256

    Google Scholar 

  18. Freeman SM, Whartenby KA, Koeplin DS, Moolten FL, Abboud CN, Abraham GN (1992) Tumor regression when a fraction of the tumor mass contains the HSV-TK gene. J Cell Biol 16F:47

    Google Scholar 

  19. Friedmann T (1992) A brief history of gene therapy. Nat Genet 2:93–98

    PubMed  Google Scholar 

  20. Friedmann T (1992) Gene therapy of cancer through restoration of tumor-suppressor functions? Cancer 70 [Suppl]:1810–1817

    PubMed  Google Scholar 

  21. Gansbacher B, Bannerji R, Daniels B, Zier K, Cronin K, Gilboa E (1990) Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long-lasting antitumor immunity. Cancer Res 50:7820–7825

    PubMed  Google Scholar 

  22. Gansbacher B, Zier K, Daniels B, Cronin K, Bannerji R, Gilboa E (1990) Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J Exp Med 172:1217–1224

    PubMed  Google Scholar 

  23. Geller AI, Keyomarsi K, Bryan J et al. (1990) An efficient deletion mutant packaging system for defective herpes simplex vectors: potential applications to human gene therapy and neuronal physiology. Proc Natl Acad Sci USA 87:8950–8954

    PubMed  Google Scholar 

  24. Golumbek PT, Lazenby AJ, Levitzky H et al. (1991) Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science 264:713–716

    Google Scholar 

  25. Graham FL, Prevec L (1992) Adenovirus-based expression vectors and recombinant vaccines. Biotechnology 20:363–390

    PubMed  Google Scholar 

  26. Graham BS, Matthews TJ, Belshe RB et al. (1993) Augmentation of human immunodeficiency virus type 1 neutralizing antibody by priming with gp160 recombinant vaccinia and boosting with rgp160 in vaccinia-naive adults. J Infect Dis 167:533–537

    PubMed  Google Scholar 

  27. Graham FL, van der Eb AJ (1973) A new technique for the assay of infectivity of human adenovirus 5-DNA. Virology 52:456–467

    PubMed  Google Scholar 

  28. Gutierrez A, Lemoine N, Sikora K (1992) Gene therapy for cancer. Lancet 339:715–721

    PubMed  Google Scholar 

  29. Hanania EG, Deisseroth AB (1994) Serial transplantation shows that early hematopoietic precursor cells are transduced by MDR-1 retroviral vector in a mouse gene therapy model. Cancer Gene Ther 1:21–25

    PubMed  Google Scholar 

  30. Hock H, Dorsch M, Diamantstein T, Blanckenstein T (1991) Interleukin-7 induces CD4+ T cell-dependent tumor rejection. J Exp Med 174:1291–1298

    PubMed  Google Scholar 

  31. Human Gene Marker/Therapy Clinical Protocols (1994) Hum Gene Ther 5:417–426

    Google Scholar 

  32. Johnston SA, Tang D (1993) The use of microparticle injection to introduce genes into animal cells in vitro and in vivo. In: Setlow JK (ed) Genetic engineering. Plenum, New York, pp 225–236

    Google Scholar 

  33. Jolly D (1994) Review article. Viral vector systems for gene therapy. Cancer Gene Ther 1:51–64

    PubMed  Google Scholar 

  34. Kashani-Sabet M, Funato T, Florenes VA, Fodstad O, Scanlan ICJ (1994) Suppression by the neoplastic phenotype in vivo by an anti-ras ribozyme. Cancer Res 54:900–902

    PubMed  Google Scholar 

  35. Kasid A, Morecki S, Aebersold P, Cornetta K, Culver K et al (1990) Human gene transfer: characterization of human tumor infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man. Proc Natl Acad Sci USA 87:473–477

    PubMed  Google Scholar 

  36. Keating A, Toneguzzo F (1990) Gene transfer by electroporation: a model for gene therapy. Prog Clin Biol Res 333:491–498

    PubMed  Google Scholar 

  37. Klein TM, Arentzen R, Lewis PA et al (1992) Transformation of microbes, plants and animals by particle bombardment. Biotechnology 10:286–291

    PubMed  Google Scholar 

  38. Le Gal La Salle G, Robert JJ, Bernard S, Ridoux V, Stratford-Perricaudet LD, Perricaudet M (1993) An adenovirus vector for gene transfer into neurons and glia in the brain. Science 259:988–990

    PubMed  Google Scholar 

  39. Li S, Polonis V, Isobe H, et al. (1993) Chimeric influenza virus induces neutralizing antibodies and cytotoxic T cells against human immunodeficiency virus type 1. J Virol 67:6659–6666

    PubMed  Google Scholar 

  40. Lim CS, Chapman GD, Gammon RS et al (1991) Direct in vivo gene transfer into the coronary and peripheral vasculatures of the intact dog. Circulation 83:2007–2011

    PubMed  Google Scholar 

  41. Lin H, Parmacek MS, Morle C, Bolling S, Leiden JM (1990) Expression of recombinant genes in myocardium in vivo after direct injection of DNA. Circulation 82:2217–2221

    PubMed  Google Scholar 

  42. Lotze et al (1994) Human Gene Ther 5:41–56

    Google Scholar 

  43. Macer D (1992) Public acceptance of human gene therapy and perceptions of human genetic manipulation. Hum Gene Ther 3:511–518

    PubMed  Google Scholar 

  44. McLachlin JR, Cornetta K, Eglitis MA, Anderson WF (1990) Retroviral-mediated gene transfer. Prog Nucleic Acids Res Mol Biol 38:91–135

    Google Scholar 

  45. McLachlin JR, Eglitis MA, Ueda K et al (1990) Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoetic precursor cells with the use of retroviral gene transfer. J Natl Cancer Inst 82:1260–1263

    PubMed  Google Scholar 

  46. Miller AD (1990) Retrovirus packaging cells. Hum Gene Ther 1:5–14

    PubMed  Google Scholar 

  47. Miller DAJ (1992) Human gene therapy comes of age. Nature 357:455–460

    PubMed  Google Scholar 

  48. Miller AD, Miller DG, Garcia JV et al (1993) Use of retroviral vectors for gene transfer and expression. Methods Enzymol 217:581–599

    PubMed  Google Scholar 

  49. Moolten FL (1990) Mosaicism induced by gene insertion as a means of improving chemotherapeutic selectivity. Crit Rev Immunol 10:203–233

    PubMed  Google Scholar 

  50. Moolten FL, Wells JM (1990) Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J Natl Cancer Inst 82:297–300

    PubMed  Google Scholar 

  51. Moolten FL, Wells JM, Heyman RA, Evans RM (1990) Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene. Hum Gene Ther 1:125–134

    PubMed  Google Scholar 

  52. Morgan R, Anderson WF (1993) Human gene therapy. Annu Rev Biochem 62:191–217

    PubMed  Google Scholar 

  53. Morgan RA, Cornetta K, Anderson WF (1990) Applications of the polymerase chain reaction in retroviral-mediated gene transfer and the analysis of gene-marked human TIL cells. Hum Gene Ther 1:135–149

    PubMed  Google Scholar 

  54. Muro-Cacho CA, Samulski RJ, Kaplan D (1992) Gene transfer in human lymphocytes using a vector based on adenoassociated virus. J Immunother 11:231–237

    PubMed  Google Scholar 

  55. Nabel EG, Plautz G, Nabel GJ (1990) Site-specific gene expression in vivo by direct gene transfer into the arterial wall. Science 249:1285–1288

    PubMed  Google Scholar 

  56. Orda Reports (1994) Recombinant DNA Advisory Committee (RAC). Data Management Report-June 1993. Hum Gene Ther 5:411–415

    Google Scholar 

  57. Porgador A, Tzehoval E, Katz A, Vadai E, Revel M, Feldman M, Eisenbach L (1992) Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells. Cancer Res 52:3679–3686

    PubMed  Google Scholar 

  58. Poznansky M, Lever A, Bergeron L et al (1991) Gene transfer into human lymphocytes by a defective human immunodeficiency virus type 1 vector. J Virol 65:532–536

    PubMed  Google Scholar 

  59. Report of the Committee on the Ethics of Gene Therapy (1992) Hum Gene Ther 3:519–523

    Google Scholar 

  60. Revised points to consider, NIH RAC (1990) Hum Gene Ther 1:93–103

    Google Scholar 

  61. Rich DP, Couture M, Cardoza LM et al (1993) Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis. Human Gene Ther 4:461–476

    Google Scholar 

  62. Rill DR, Buschle M, Foreman NK et al (1992) Retrovirusmediated gene transfer as an approach to analyze neuroblastoma relapse after autologous bone marrow transplantation. Hum Gene Ther 3:129–136

    PubMed  Google Scholar 

  63. Rosenberg SA (1992) The immunotherapy and gene therapy of cancer. J Clin Oncol 10:180–199

    PubMed  Google Scholar 

  64. Rosenberg SA, et al. (1992) Immunization of cancer patients using autologous cancer cells modified by insertion of the gene for tumor necrosis factor. Hum Gene Ther 3:57–73

    PubMed  Google Scholar 

  65. Rosenberg SA, Aebersold P, Cornetta K, Kasid A, Morgan RA, Moen RC et al (1990) Gene transfer into humans — immunotherapy of patients with advanced melanoma, using tumor infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med 326:370–378

    Google Scholar 

  66. Rosenberg SA, Lotze MT, Muul LM et al (1987) A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med 316:889–897

    PubMed  Google Scholar 

  67. Scanlon KJ, Jiao L, Funato T, Wang W, Tone T, Rossi JJ, Kashani SM (1991) Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein. Proc Natl Acad Sci USA 88:10591–10595

    PubMed  Google Scholar 

  68. Schmidt-Wolf IGH (1994) Phase I study: interleukin-7 gene therapy for patients with metastatic colon cancer, renal cell cancer, malignant melanoma or lymphoma. Cancer Gene Ther (in press)

  69. Schmidt-Wolf IGH, Neubauer A, Finke S, Csipai M, Wittig B, Huhn D (1994) Interleukin-7 gene therapy for patients with metastatic colon cancer, renal cell cancer, malignant melanoma or lymphoma. Hum Gene Ther (in press)

  70. Short MP, Shoi BC, Lee JK, Malick A, Breakefield XO, Martuza RL (1990) Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line. J Neurosci Res 27:427–439

    PubMed  Google Scholar 

  71. Skorski T, Nieborowskaskorska M, Barletta C, Malaguarnera L, Szeczylik C, Chen ST, Lange B, Calabretta B (1993) Highly efficient elimination of Philadelphia leukemic cells by exposure to bcr/abl antisense oligodeoxynucleotides combined with mafosfamide. J Clin Invest 92:194–202

    PubMed  Google Scholar 

  72. Sorrentino BP, Brandt SJ, Bodine D et al (1992) Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. Science 257:99–103

    PubMed  Google Scholar 

  73. Sukharev SJ, Klenchin VA, Serov SM, Chernomordik LV, Chizmadzhev YA (1992) Electroporation and electroporetic DNA transfer into cells. Biophys J 63:1320–1327

    PubMed  Google Scholar 

  74. Swinbanks D (1993) Japan reviews first guidelines for gene therapy trials (news). Nature 362:684

    Google Scholar 

  75. Takamiya Y, Short MP, Ezzeddine ZD, Moolten FL, Breakefield XO, Martuza RL (1992) Gene therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type 1-thymidine kinase gene and wild type retrovirus kills other tumor cells. J Neurosci Res 33:493–503

    PubMed  Google Scholar 

  76. The ADA human gene therapy clinical protocol (1990) Hum Gene Ther 1:327–362

    Google Scholar 

  77. The N2-TIL human gene transfer clinical protocol (1990) Hum Gene Ther 1:73–92

    Google Scholar 

  78. The TNF/TIL Human Gene Therapy Clinical Protocol (1990) Hum Gene Ther 1:441–480

    Google Scholar 

  79. The University of Texas M.D. Anderson Cancer Center (1991) Autologous bone marrow transplantation for CML in which retroviral markers are used to discriminate between relapse which arises from systemic disease remaining after preparative therapy versus relapse due to residual leukemia cells in autologous marrow: a pilot trial. Hum Gene Ther 2:359–376

    Google Scholar 

  80. Tolstoshev P (1992) Retroviral-mediated gene therapy — safety considerations and preclinical studies. Bone Marrow Transplant 9 [Suppl 1] 148–150

    PubMed  Google Scholar 

  81. Tolstoshev P (1993) Gene therapy, concepts, current trials and future directions. Annu Rev Pharmacol Toxicol 32:573–596

    Google Scholar 

  82. Tolstoshev P, Anderson WF (1990) Gene expression using retroviral vectors. Curr Opin Biotechnol 1:55–61

    PubMed  Google Scholar 

  83. Tolstoshev P, Anderson WF (1993) Gene transfer techniques for use in human gene therapy. In: Adolph KW (ed) Techniques and applications of genome research. Academic, New York

    Google Scholar 

  84. Anonymous (1990) Treatment of patients with advanced cancer using cyclophosphamide, interleukin-2, and gene-marked tumor infiltrating lymphocytes. Hum Gene Ther 1:73

  85. Trojan J, Johnson TR, Rudin SD, Ilan J, Tykocinski ML (1993) Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA. Science 259:94–97

    PubMed  Google Scholar 

  86. Tseng BY, Brown KD (1994) Antisense oligonucleotide technology in the development of cancer therapeutics. Cancer Gene Ther 1:65–71

    PubMed  Google Scholar 

  87. Unterhuber R (1993) Gene therapy gathers speed in Germany. Nature 365:197

    PubMed  Google Scholar 

  88. Vile RG, Ali M, Hunter E et al (1992) Identification of a generalised packaging sequence for D-type retroviruses and generation of a D-type retroviral vector. Virology 189:786–791

    PubMed  Google Scholar 

  89. Wachter de Mam (1993) Experimental (somatic) gene therapy. Ethical concerns and control. Manuscript, Institute for Bioethics, Maastricht, p 79

    Google Scholar 

  90. Walz C, Schlehofer JR (1992) Modification of some biological properties of Hela cells containing adeno-associated virus DNA integrated into chromosome 17. J Virol 66:2990–3002

    PubMed  Google Scholar 

  91. Wei CM, Gibson M, Spear PG et al (1981) Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1. J Virol 39:935–944

    PubMed  Google Scholar 

  92. Williams RS, Johnston SA, Riedy M et al (1991) Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. Proc Natl Acad Sci USA 88:2726–2730

    PubMed  Google Scholar 

  93. Wilson JM, Grossman M, Wu CH, Chowdhury NR, Wu GY, Chowdhury JR (1992) Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterinemia in low-density lipoprotein receptor-deficient rabbits. J Biol Chem 267:963–967

    PubMed  Google Scholar 

  94. Wu GY, Wilson JM, Shlaby F, Grossman M, Shafritz DA, Wu CH (1991) Receptor-mediated gene delivery in vivo. J Biol Chem 266:14338–14342

    PubMed  Google Scholar 

  95. Wu CH, Wilson JM, Wu GY (1989) Targeting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo. J Biol Chem 264:16985–16987

    PubMed  Google Scholar 

  96. Zenke M, Steinlein P, Wagner E, Matthew C, Beug H, Birnstiel ML (1990) Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells. Proc Natl Acad Sci USA 87:3655–3659

    PubMed  Google Scholar 

  97. Zhao S-C, Li M-X, Banerjee D, Schweitzer BI, Mineishi S, Gilboa E, Bertino JR (1994) Long-term protection of recipient mice from lethal doses of methotrexate by marrow infected with a double-copy vector retrovirus containing a mutant dihydrofolate reductase. Cancer Gene Ther 1:27–33

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schmidt-Wolf, G., Schmidt-Wolf, I.G.H. Human cancer and gene therapy. Ann Hematol 69, 273–279 (1994). https://doi.org/10.1007/BF01696555

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01696555

Keywords

Navigation