Summary
The association of pregnancy and splenic vein thrombosis is rare. The authors describe four patients who had acute painful splenomegaly in association with pregnancy. All patients had a slightly elevated platelet count in the nonpregnant state and had at least one spontaneous abortion. One patient had transient neurologic symptoms, and two others had a history of gastric ulcer. The splenic thrombosis occurred in the 9th (in two cases) and in the 13th week of gestation (in two cases), and 1 week after abortion (in two cases). Three patients under-went splenectomy and one refused it. All patients had persistent thrombocythemia after the splenectomy. In three patients the platelet count reversibly dropped at least 50% during pregnancy. Of their 19 pregnancies, one resulted in normal birth, one in preterm birth, two in therapeutic abortion, and 15 in spontaneous abortion. Data presented suggest that the latent form or early stage of a myeloproliferative disorder may contribute to both splenic and placental thrombosis.
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References
Beard MEJ, Baker BW (1989) Spontaneous remission of essential thrombocythemia during two consecutive pregnancies. Eur J Haematol 43: 348–349
Falconer J, Pineo G, Blahey W, Bowen T, Docksteader B, Jadusingh I (1987) Essential thrombocythemia associated with recurrent abortions and fetal growth retardation. Am J Hematol 25: 345–347
Johnson PM, Davies JM, Rand J (1989) Thrombocythaemia and recurrent miscarriage. Br J Obstet Gynaecol 96: 1231–1232
Jones EC, Mosesson MW, Thomason JL, Jackson TC (1988) Essential thrombocythemia in pregnancy. Obstet Gynecol 71: 501–503
Kaibara M, Kobayashi T, Matsumoto S (1985) Idiopathic thrombocythemia and pregnancy: report of a case. Obstet Gynecol 65: 18S-19S
Mercer B, Drouin J, Jolly E, d'Anjou G (1988) Primary thrombocythemia in pregnancy: a report of two cases. Am J Obstet Gynecol 159: 127–128
Murphy S (1982) Disorders of platelet production. In: Colman RW, Hirsch J, Marder VJ, Salzman EW (eds) Hemostasis and thrombosis. Lippincott, Philadelphia, pp 259–273
Pajor A, Lehoczky D (1990) Pregnancy and extrahepatic portal hypertension. Review and report on the management. Gynecol Obstet Invest 30: 193–197
Pitkin RM, White DL (1979) Platelet and leukocyte counts in pregnancy. JAMA 242: 2696–2698
Snethlage W, Cate JWT (1986) Thrombocythaemia and recurrent late abortions: normal outcome of pregnancies after antiaggregatory treatment. Case report. Br J Obstet Gynaecol 93: 386–388
Turhan AG, Humphries RK, Cashman JD, Cuthbert DA, Eaves CJ, Eaves AC (1988) Transient suppression of clonal hemopoiesis associated with pregnancy in a patient with a myelopro-liferative disorder. J Clin Invest 81: 1999–2003
Valla D, Casadevall N, Huisse MG, Tulliez M, Grange JD, Muller O, Binda T, Varet B, Rueff B, Benhamou JP (1988) Etiology of portal vein thrombosis in adults. Gastroenterology 94: 1063–1069
Webb LJ, Sherlock S (1979) The aetiology, presentation and natural history of extrahepatic portal venous obstruction. Q J Med 48: 627–639
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Pajor, A., Lehoczky, D. Splenic thrombosis complicating pregnancy in patients with poor obstetrical outcome a report of four cases. Ann Hematol 66, 319–321 (1993). https://doi.org/10.1007/BF01695975
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DOI: https://doi.org/10.1007/BF01695975