Skip to main content
Log in

A young man with fever, splenomegaly, hepatic granulomas, and lymphocytic bone marrow infiltrates

  • Clinicopathologic Conference
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Abrams J, Pearl P, Moody M, Schimpff SC (1988) Epithelioid granulomas revisited: long-term follow-up in Hodgkin's disease. Am J Clin Oncol (CCT) 11: 456–460

    Google Scholar 

  2. Bottone EJ, Sheehan DJ (1983)Yersinia enterocolitica: guidelines for serologic diagnosis of human infections. Rev Infect Dis 5: 898–906

    Google Scholar 

  3. Brincker H (1990) Granulomatous lesions of unknown significance in biopsies from lymph nodes and other tissues: the GLUS-syndrome. Sarcoidosis 7: 28–30

    Google Scholar 

  4. Case records of the Massachusetts General Hospital (1983) Weekly clinicopathological exercises. Case 12: a 78-year-old woman with persistent fever of unknown origin. N Engl J Med 308: 705–713

    Google Scholar 

  5. Casey TT, Cousar JB, Collins RD (1988) A simplified plastic embedding and immunohistologic technique for immunophenotypic analysis of human hematopoietic and lymphoid tissues. Am J Pathol 131: 183–189

    Google Scholar 

  6. Choe JK, Hyun BH, Salazar GH, Ashton JK, Sung C (1983) Epithelioid granulomas of the bone marrow in non-Hodgkin's lymphoproliferative malignancies. Am J Clin Pathol 80: 19–24

    Google Scholar 

  7. Cunningham D, Mills PR, Quigley EMM, Patrick RS, Watkinsons G, MacKenzie JF, Russell RI (1982) Hepatic granulomas: experience over a 10-year period in the West of Scotland. Q J Med 51: 162–170

    Google Scholar 

  8. Ellman L (1976) Bone marrow biopsy in the evaluation of lymphoma, carcinoma and granulomatous disorders. Am J Med 60: 1–7

    Google Scholar 

  9. Farhi DC, Mason UG III, Horsburgh CR Jr (1985) The bone marrow in disseminatedMycobacterium avium-intracellulare infection. Am J Clin Pathol 83: 463–468

    Google Scholar 

  10. Farhi DC, Mason UG III, Horsburgh CR Jr (1986) Pathologic findings in disseminatedMycobacterium avium-intracellulare infection: a report of 11 cases. Am J Clin Pathol 85: 67–72

    Google Scholar 

  11. Gerben MA, MacAllistar TJ, Ballow M, Sedgwick AK, Gustafson KB, Tilton RC (1985) The aetiological agent of cat scratch disease. Lancet 1: 1236–1239

    Google Scholar 

  12. Guckian JC, Perry JE (1966) Granulomatous hepatitis. An analysis of 63 cases and review of the literature. Ann Intern Med 65: 1081–1100

    Google Scholar 

  13. Harrington PT, Gutierrez JJ, Ramirez-Ronda CH, Quinones-Soto R, Bermudez RH, Chaffey J (1982) Granulomatous hepatitis. Rev Infect Dis 4: 638–655

    Google Scholar 

  14. Heesemann J, Eggers C, Schroder J (1987) Serological diagnosis of yersiniosis by immunoblot technique using virulence-associated antigen of enteropathogenic Yersiniae. Contrib Microbiol Immunol 9: 285–289

    Google Scholar 

  15. Hoogkamp-Korstanje JAA, de Koning J, Samson JP (1986) Incidence of human infection withYersinia enterocolitica serotypes 03, 08, and 09 and the use of indirect immunofluorescence in diagnosis. J Infect Dis 153: 139–141

    Google Scholar 

  16. Hoogkamp-Korstanje JAA, de Koning J, Heesemann J (1988) Persistence ofYersinia enterocolitica in man. Infection 16: 81–85

    Google Scholar 

  17. Kim H, Dorfman RF (1974) Morphological studies of 84 untreated patients subjected to laparotomy for staging of non-Hodgkin's lymphomas. Cancer 33: 657–674

    Google Scholar 

  18. Klatskin G (1976) Hepatic granulomata. Problems in interpretation. Ann NY Acad Sci 278: 427–432

    Google Scholar 

  19. Kluin-Nelemans JC, Noordijk EM (1990) Staging of patients with Hodgkin's disease: what should be done? Leukemia 4: 132–135

    Google Scholar 

  20. Koning J de, Heesemann J, Hoogkamp-Korstanje JAA, Festen JJM, Houtman PM, van Oijen PLM (1989)Yersinia in intestinal biopsy specimens from patients with seronegative spondylarthropathy: correlation with specific serum IgA antibodies. J Infect Dis 159: 109–112

    Google Scholar 

  21. Maddrey WC, Johns CJ, Boinott JK, Iber FL (1970) Sarcoidosis and chronic hepatic disease. A clinical and pathological study of 20 patients. Medicine (Baltimore) 49: 375–395

    Google Scholar 

  22. Meadows LM, Rosse WR, Moore JO, Crawford J, Laszlo J, Kaufman RE (1989) Hodgkin's disease presenting as myelofibrosis. Cancer 64: 1720–1726

    Google Scholar 

  23. Neiman RS (1977) Incidence and importance of splenic sarcoid-like granulomas. Arch Pathol Lab Med 101: 518–521

    Google Scholar 

  24. O'Carroll DI, McKenna RW, Brunning RD (1976) Bone marrow manifestations of Hodgkin's disease. Cancer 38: 1717–1728

    Google Scholar 

  25. O'Connell MJ, Schimpff SC, Kirschner RH, Abt AB, Wiernik PH (1975) Epithelioid granulomas in Hodgkin's disease. A favorable prognostic sign? JAMA 233: 886–889

    Google Scholar 

  26. Pak HY, Friedman NB (1981) Pseudosarcoid granulomas in Hodgkin's disease. Hum Pathol 12: 832–837

    Google Scholar 

  27. Patchefsky AS, Brodovsky H, Southard M, Menduke H, Gray S, Hoch WS (1973) Hodgkin's disease: a clinical and pathologic study of 235 cases. Cancer 32: 150–161

    Google Scholar 

  28. Patel KM (1981) Granulomatous hepatitis due toMycobacterium scrofulaceum. Report of a case. Gastroenterology 81: 156–158

    Google Scholar 

  29. Pieron R, Mafart Y, Lesobre B, Zurbach J, Ferraud D, Meyniel D (1980) Fièvre, granulomatose hépatique, troubles électrocardiographiques et sero-diagnostic positif pour yersinia enterocolitica: deux observations. Ann Med Interne 131: 353–355

    Google Scholar 

  30. Sherlock S (1989) Hepatic granulomas. In: Diseases of the liver and biliary system. Blackwell Scientific, Boston, pp 535–542

    Google Scholar 

  31. Stewart C, Jackson L (1976) Spleno-hepatic tuberculosis due toMycobacterium kansasii. Med J Aust 2: 99–101

    Google Scholar 

  32. Stjernberg U, Silseth C, Ritland S (1987) Granulomatous hepatitis inYersinia enterocolitica infection. Hepato-gastroenterol 34: 56–57

    Google Scholar 

  33. Tak PP, Visser LG, Hoogkamp-Korstanje JAA, Kluin-Nelemans JC, Hogendoorn PCW, Kluin PhM, Barza M, de Koning J, van Furth R (1992) Unusual manifestations ofYersinia enterocolitica infections diagnosed by novel diagnostic methods. Clin Infect Dis 15: 645–649

    Google Scholar 

  34. Warthin AS, Starry AC (1920) More rapid and improved method of demonstrating spirochetes in tissues. Am J Syph 4: 97–103

    Google Scholar 

  35. Worthington MG, O'Donnell KF, Dowling JJ, Murphy T, Whitmore EL (1984) Granulomatous hepatitis inYersinia enterocolitica bacteraemie. J Infect 9: 170–173

    Google Scholar 

  36. Wyler DJ, Wolff SM (1987) Granulomatous liver disease. In: Schiff L, Schiff ER (eds) Diseases of the liver. Lippincott, Philadelphia, pp 1438–1442

    Google Scholar 

  37. Yardley JH, Paull G (1988)Campylobacter pylori: a newly recognized infectious agent in the gastrointestinal tract. Am J Surg Pathol 12 [Suppl 1]: 89

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tak, P.P., Kluin, P.M., Hoogkamp-Korstanje, J.A.A. et al. A young man with fever, splenomegaly, hepatic granulomas, and lymphocytic bone marrow infiltrates. Ann Hematol 66, 97–102 (1993). https://doi.org/10.1007/BF01695892

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01695892

Keywords

Navigation