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Histoplasmosis in hairy cell leukemia: Case report and review of the literature

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Summary

Progressive disseminated histoplasmosis (PDH) has been described in only six patients with hairy cell leukemia (HCL). Herein we describe an additional patient with HCL and disseminated histoplasmosis. Additionally, we note that three of seven cases of disseminated histoplasmosis and HCL have occurred in East Texas. PDH is to be suspected in febrile HCL patients in an endemic area who fail to respond to antibacterial therapy. We emphasize that serologic studies are useful in the diagnosis of PDH in HCL patients, and these patients respond well to therapy.

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References

  1. Anderson KC, Boyd AW, Fisher DC, Leslie D, Schlossman SF, Nadler LM (1985) Hairy cell leukemia: a tumor of pre-plasma cells. Blood 65: 620–629

    PubMed  Google Scholar 

  2. Baldini L, Cortelezzi A, Polli N, Neri A, Nobili L, Maiolo AT, Lambergenghi-Deliliers G, Polli EE (1986) Human recombinant interferon α-2 C enhances the expression of class-II HLA antigens of hairy cells. Blood 67: 458–464

    PubMed  Google Scholar 

  3. Bennett CL, Westbrook CA, Gruber B, Golomb HM (1986) Hairy cell leukemia and mucormycosis. Am J Med 81: 1065–1067

    PubMed  Google Scholar 

  4. Bouroncle BA (1979) Leukemic reticuolendotheliosis (hairy cell leukemia). Blood 53: 609–630

    Google Scholar 

  5. Bouroncle BA, Wiesman BK, Doan CA (1958) Leukemic reticuloendotheliosis. Blood 13: 509–630

    Google Scholar 

  6. Bouza E, Burgaleta C, Golde DW (1978) Infections in hairy cell leukemia. Blood 51: 851–859

    PubMed  Google Scholar 

  7. Child JA, Cawley JC, Martin S, McGhoneim AT (1979) Microbicidal function of the neutrophils in hairy-cell leukaemia. Acta Haematol (Basel) 62: 191–198

    Google Scholar 

  8. Cox F, Hughes WT (1974) Disseminated histoplasmosis and childhood leukemia. Cancer 33: 1127–1133

    PubMed  Google Scholar 

  9. Daves SF, Khan M, Sarosi GA (1978) Disseminated histoplasmosis in immunology-suppressed patients. Am J Med 64: 95–100

    Google Scholar 

  10. Deepe GS jr (1988) Protective immunity in murine histoplasmosis; Functional comparison of adoptively transferred T-cell clones and splenic T-cells. Infect Immun 65: 2350–2355

    Google Scholar 

  11. Dismukes WE, Royal SA, Tynes BS (1978) Disseminated histoplasmosis in corticosteroid-treated patients. Report of five cases. JAMA 240: 1495–1498

    PubMed  Google Scholar 

  12. Edwards IB, Acquaviva FA, Livesay VT, et al. (1969) An atlas of sensitivity to tuberculin. PPD-B and histoplasmosis in the UNited States. Am Rev Respir Dis 99: 1

    Google Scholar 

  13. Golomb HM, Hadad LJ (1984) Infectious complications in 127 patients with hairy cell leukemia. Am J Hematol 16: 393–401

    PubMed  Google Scholar 

  14. Golomb HM, Hanover SB (1981) Infectious complications associated with hairy cell leukemia. J Infect Dis 5: 639–643

    Google Scholar 

  15. Goodwin RA, Shapiro JL, Thurman GH, et al. (1980) Disseminated histoplasmosis: Clinical and pathologic correlations. Medicine (Baltimore) 59: 1–33

    Google Scholar 

  16. Gualtieri RJ, Wheby MS (1984) Hairy cell leukemia: a case of cryptococcosis appearing as hairy cell meningitis. South Med J 77: 1341–1342

    PubMed  Google Scholar 

  17. Hersch EV, Quesada J, Keating MJ, Rasmussen S, Murphy SG, Gschwind C, Morgan J (1982) Host defense factors and prognosis in hairy cell leukemia. Leukemia Res 6: 625–637

    Google Scholar 

  18. Hsu S-M, Yang K, Jaffé ES (1983) Hairy cell leukemia: a B-cell neoplasm with a unique antigenic phenotype. Am J Clin Pathol 80: 421–428

    PubMed  Google Scholar 

  19. Janckila AJ, Wallace JH, Yam LT (1982) Generalized monocyte deficiency in leukaemic reticuloendotheliosis. Scan J Haematol 29: 153–160

    Google Scholar 

  20. Johnson PC, Khardoi N, Najjar AF, et al. (1988) Progressive disseminated histoplasmosis in patients with acquired immunodeficiency syndrome. Am J Med 85: 152–158

    PubMed  Google Scholar 

  21. Katayama I, Finkel HL (1974) Leukemic reticuloendotheliosis. A clinicopathologic study with review of the literature. Am J Med 57: 115–126

    PubMed  Google Scholar 

  22. Kauffman CA, Israel KS, Smith JW, White AC, Schwarz J, Brooks GF (1978) Histoplasmosis in immunosuppressed patients. Am J Med 64: 923–932

    PubMed  Google Scholar 

  23. Lehmann PF, Gibbons J, Senitzer D, Ribner BS, Freimer EH (1983) T-lymphocyte abnormalities in disseminated histoplasmosis. J Med 75: 790–794

    PubMed  Google Scholar 

  24. Libshitz HI, Shuman LS, Gresik MV, Heaston DK (1981) Pneumonia in hairy cell leukemia. Radiology 139: 19–24

    PubMed  Google Scholar 

  25. Mackowiak PA, Demian SE, Sutker WL, et al. (1980) Infections in hairy cell leukemia. Clinical evidence of a pronounced defect in cell-mediated immunity. Am J Med 68: 718–724

    PubMed  Google Scholar 

  26. Mackowiak PA, Demian SE, Sutker WL, Murphy FK, Smith JW, Tompsett R, Sheehan WW, Luby JP (1980) Infections in hairy cell leukemia. Clinical evidence of a pronounced defect in cell-mediated immunity. Am J Med 68: 718–724

    PubMed  Google Scholar 

  27. Mario JP, Degas L, Flandrin G (1977) Hairy cell leukemia and tuberculosis. (Letter) N Engl J Med 296: 354

    Google Scholar 

  28. Palmer CE (1946) Geographic differences in sensitivity to histoplasmin among student nurses. Public Health Rep 61: 475

    Google Scholar 

  29. Payan DG, Wheat LJ, Brahmi Z, Ip S, Hansen WP, Hoffman RA, Healey K, Rubin RH (1984) Changes in immunoregulatory lymphocyte populations in patients with histoplasmosis. J Clin Immunol 4: 98–107

    PubMed  Google Scholar 

  30. Posnett DN, Duggan A, McGrath H (1990) Hairy cell leukemia-associated antigen (HC2) is an activation antigen of several hemopoietic cell lineages, inducible on monocytes by IFN-γ1. J Immunol 144: 929–933

    PubMed  Google Scholar 

  31. Rex JH, Harris RL, Wheeler, et al. (1985) Granulomatous disease complicating hairy cell leukemia. Tex Med 81: 31–33

    Google Scholar 

  32. Rice L, Shenkenberg T, Lynch EC, et al. (1982) Granulomateus infections complicating hairy cell leukemia. Cancer 49: 1924–1928

    PubMed  Google Scholar 

  33. Rice L, Shenkenburg T, Lynch EC, Wheeler TM (1982) Granulomatous infections complicating hairy cell leukemia. Cancer 49: 1924–1928

    PubMed  Google Scholar 

  34. Rich AR (1930) The demonstration that allergic inflammation is not necessary for the operation of acquired immunity. Proc Natl Acvad Sci USA 16: 460–464

    Google Scholar 

  35. Rich AR, McCordock HA (1929) An enquiry concerning the role of allergy, immunity and other factors of importance in the pathogenesis of human tuberculosis. Bull Johns Hopkins Hosp 44: 273–423

    Google Scholar 

  36. Rich AR, Jennings FB jr, Downing LM (1933) The persistence of immunity after the abolition of allergy by desensitization. Bull John Hopkins Hosp 53: 172–196

    Google Scholar 

  37. Sathapatayavongs B, Batteiger BE, Wheat J, Slama TG, Wass JL (1983) Clinical and laboratory features of disseminated histoplasmosis during two large urban outbreaks. Medicine (Baltimore) 62: 263–270

    Google Scholar 

  38. Seshadri RS, Brown EJ, Zipursky A (1976) Leukemic reticuloendotheliosis. A failure of monocyte production. N Engl J Med 295: 181–184

    PubMed  Google Scholar 

  39. Stewart DJ, Bodey GP (1981) Infections in hairy cell leukemia (leukemic reticuloendotheliosis). Cancer 47: 801–805

    PubMed  Google Scholar 

  40. Sugar AM, Stevens DA (1985)Candida rugosa in immunocompromised infection. Cancer 56: 318–320

    PubMed  Google Scholar 

  41. Trentin L, Zambello R, Agostini C, Ambrosetti A, Chisesi T, Raimondi R, Bulian P, Pizzolo G, Semenzato G (1990) Mechanisms accounting for the defective natural killer activity in patients with hairy cell leukemia. Blood 75: 1525–1530

    PubMed  Google Scholar 

  42. Wheat J, French MLV, Kohler RB, Zimmerman SE, Smith WR, Norton JA, Eitzen HE, Smith CD, Slama TG (1982) The diagnostic laboratory tests for histoplasmosis — analysis of experience in a large urban outbreak. Ann Intern Med 97: 680–685

    PubMed  Google Scholar 

  43. Wheat LJ, Slama TG, Norton JA, et al. (1982) Risk factors for disseminated or fatal histoplasmosis. Ann Intern Med 96: 159–163

    PubMed  Google Scholar 

  44. Wu-Hsieh B, Howard DH (1984) Inhibition of growth ofHistoplasma capsulatum by lymphokine-stimulated macrophages. J Immunol 132: 2593–2597

    PubMed  Google Scholar 

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Author information

Author notes

  1. E. Weeks

    Present address: Oncology and Hematology Consultants, 3810, Memphis, Tennessee, USA

  2. G. A. Sarosi

    Present address: Department of Medicine, Maricopa Medical Center, Phoenix, Arizona, USA

  3. P. A. Bunnell

    Present address: Port LaVaca Clinical Associates, Port LaVaca, Texas, USA

Authors and Affiliations

  1. Divisions of Hematology and General Medicine, University of Texas Medical School at Houston, Texas

    E. Weeks, C. M. Jones, V. Guinee, R. Shallenberger, G. A. Sarosi & P. A. Bunnell

  2. Departments of Hematology and Patient Studies, M. D. Anderson Cancer Center, Texas, USA

    E. Weeks, C. M. Jones, V. Guinee, R. Shallenberger, G. A. Sarosi & P. A. Bunnell

Authors
  1. E. Weeks
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  2. C. M. Jones
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  3. V. Guinee
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  4. R. Shallenberger
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  5. G. A. Sarosi
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  6. P. A. Bunnell
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Additional information

Dr. Weeks was supported by a Training Grant from the American Cancer Society to MD Anderson Cancer Center Medical School Houston, Texas 77030, 6431 Fannin Street, Rm 5016 M.S.M.B.

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Weeks, E., Jones, C.M., Guinee, V. et al. Histoplasmosis in hairy cell leukemia: Case report and review of the literature. Ann Hematol 65, 138–142 (1992). https://doi.org/10.1007/BF01695814

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  • DOI: https://doi.org/10.1007/BF01695814

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