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Plasma cell leukemia with myelofibrosis

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Summary

We describe a case of plasma cell leukemia associated with myelofibrosis. A 60-year-old woman was admitted due to lumbago and monoclonal hypergammaglobulinemia. Peripheral blood showed about 40% of plasma-cell-like cells. A bone marrow aspiration was dry tap. The patient was diagnosed as having plasma cell leukemia with myelofibrosis by bone marrow biopsy. Plasma cell leukemia as well as myelofibrosis improved with combination chemotherapy using vincristine, pirarubicin, and dexamethasone. However, when plasma cell leukemia became resistant to chemotherapies, myelofibrosis also reappeared. This case strongly suggests the pathogenetic relationship between plasma cell leukemia and myelofibrosis.

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Authors and Affiliations

  1. Third Division, Department of Medicine, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, 650, Kobe, Japan

    T. Murayama, T. Matsui, T. Taniguchi, M. Ito, T. Natazuka, S. Imoto, N. Iwata & K. Chihara

  2. First Division, Department of Pathology, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, 650, Kobe, Japan

    Y. Hayashi & H. Ito

  3. School of Allied Medical Sciences, Kobe University, 7-10-2 Tomogaoka, Suma-ku, 654-01, Kobe, Japan

    T. Isobe

Authors
  1. T. Murayama
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  2. T. Matsui
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  3. Y. Hayashi
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  4. T. Taniguchi
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  5. M. Ito
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  6. T. Natazuka
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  7. S. Imoto
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  8. N. Iwata
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  9. T. Isobe
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  10. H. Ito
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  11. K. Chihara
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Murayama, T., Matsui, T., Hayashi, Y. et al. Plasma cell leukemia with myelofibrosis. Ann Hematol 69, 151–152 (1994). https://doi.org/10.1007/BF01695697

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  • DOI: https://doi.org/10.1007/BF01695697

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