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In vitro activity of ceftizoxime, ceftazidime, cefuroxime, ceftriaxone, cefotaxime, and penicillin againstStreptococcus pneumoniae as determined by three quantitative methods

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Abstract

E-test, broth microdilution, and agar dilution susceptibility tests were used to evaluate penicillin and five extended-spectrum cephalosporins against 196 strains ofStreptococcus pneumoniae with different levels of penicillin resistance. Oxacillin disk tests corresponded to minimum inhibitory concentrations of penicillin determined by the E-test better than those generated by broth microdilution or agar dilution methods. Relative potency of the study drugs was as follows: cefotaxime=ceftriaxone > penicillin > cefuroxime > ceftizoxime > ceftazidime.

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Authors and Affiliations

  1. The Clinical Microbiology Institute, P.O. Box 947, 97062, Tualatin, Oregon, USA

    A. L. Barry, S. D. Brown & P. C. Fuchs

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  1. A. L. Barry
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  2. S. D. Brown
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  3. P. C. Fuchs
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Barry, A.L., Brown, S.D. & Fuchs, P.C. In vitro activity of ceftizoxime, ceftazidime, cefuroxime, ceftriaxone, cefotaxime, and penicillin againstStreptococcus pneumoniae as determined by three quantitative methods. Eur. J. Clin. Microbiol. Infect. Dis. 15, 344–346 (1996). https://doi.org/10.1007/BF01695670

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  • DOI: https://doi.org/10.1007/BF01695670

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