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Acquisition of syncytium-inducing HIV-1 strains during therapy with zidovudine alone or combined with alpha interferon or didanosine

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Abstract

The effect of antiretroviral treatment on HIV-1 phenotype was studied in a group of 83 nucleoside-naive patients. These initially nonsyncytium-inducing HIV-1 positive patients were followed prospectively for their HIV-1 phenotype. Syncytium-inducing variants were detected by cocultivation of peripheral blood mononuclear cells with the MT-2 T-cell line. Overall, 16 of 83 (19%) patients underwent a shift to syncytium-inducing phenotype: 11 of 67 during zidovudine treatment, 3 of 10 during zidovudine plus alpha interferon treatment, and 2 of 6 under initial zidovudine plus didanosine therapy. The results of this study demonstrate that neither zidovudine therapy alone nor combined with interferon or didanosine prevents the acquisition of syncytium-inducing strains.

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Authors and Affiliations

  1. Department of Biochemistry, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain

    Y. Torres & C. Rey

  2. Department of Internal Medicine, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain

    M. Leal, F. J. Medrano, A. Sánchez-Quijano & E. Lissen

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  1. Y. Torres
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  2. M. Leal
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  3. C. Rey
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  4. F. J. Medrano
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  5. A. Sánchez-Quijano
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  6. E. Lissen
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Torres, Y., Leal, M., Rey, C. et al. Acquisition of syncytium-inducing HIV-1 strains during therapy with zidovudine alone or combined with alpha interferon or didanosine. Eur. J. Clin. Microbiol. Infect. Dis. 15, 324–327 (1996). https://doi.org/10.1007/BF01695665

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