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Five-day versus ten-day treatment of acute otitis media with cefprozil

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Abstract

A randomized comparative clinical trial was conducted to investigate the possibility of decreasing the duration of treatment of acute otitis media by comparing the clinical out-come and safety of a five-day and a ten-day course of cefprozil. A total of 708 pediatric patients were enrolled in the study, 560 of whom were evaluable for efficacy. Cefprozil was found to be completely effective in 87.1 % of cases after five days of treatment, and in 91.2% after ten days of treatment. Of 19 patients with three or more previous episodes of acute otitis media, ten patients in the ten-day treatment group had a 100% cure rate, while in the five-day group four experienced cure, three improvement, and two failure. A five-day course of treatment with cefprozil can be recommended only if children have no history of recurrent acute otitis media.

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References

  1. Bass JW, Cashman TM, Frostad AL, Yamaoka RM, Schooler RA, Dierdorff EP: Antimicrobials in the treatment of acute otitis media. A second clinical trial. American Journal of Diseases of Children 1973, 125: 397–403.

    PubMed  Google Scholar 

  2. Strickler GB, McBean JB: The treatment of acute otitis media in children. II: A second clinical trial. Journal of the American Medical Association 1964, 187: 85–89.

    PubMed  Google Scholar 

  3. van Buchem PL, Dunk JHM, van't Hof MA: Therapy of acute otitis media: myringotomy, antibiotics or neither? Lancet 1981, ii: 883–887.

    Google Scholar 

  4. Meistrup-Larsen KI, Sorensen H, Johnsen NJ, Thomsen J, Mygind N, Sedrberg-Olsen J: Two versus seven days penicillin treatment for acute otitis media. Acta Otolaryngologica 1983, 96: 99–104.

    Google Scholar 

  5. Chaput de Saintonge DM, Levine DF, Templae Savage I, Burgess GWS, Sharp J, Mayhew SR, Salder MG, Moody R, Griffiths R, Griffiths S, Meadows G: Trial of three-day and ten-day courses of amoxycillin in otitis media. British Medical Journal 1982, 284: 1078–1081.

    PubMed  Google Scholar 

  6. Hendrickse WA, Kusmiesz H, Shelton S, Nelson JD: Five versus ten days of therapy for acute otitis media. Pediatric Infectious Disease Journal 1988, 7: 14–23.

    PubMed  Google Scholar 

  7. Aldrige KE, Shiro DD, Sanders CV: Comparative in vitro activity of the new oral cephalosporin BMY-28100. European Journal of Clinical Microbiology 1987, 6: 170–172.

    PubMed  Google Scholar 

  8. Scribner RK, Marks Ml, Finkhouse BD: In vitro activity of BMY-28100 against common bacteria isolated from pediatric infections. Antimicrobial Agents and Chemotherapy 1987, 31: 630–631.

    PubMed  Google Scholar 

  9. Kafetzis DA: Multi-investigator evaluation of the efficacy and safety of cefprozil, amoxicillin-clavulanate, cefixime and cefaclor in the treatment of acute otitis media. European Journal of Clinical Microbiology & Infectious Diseases 1994, 13: 857–865.

    Google Scholar 

  10. Mandel EM, Bluestone CD, Rockette HE, Blatter MM, Reisinger KS, Wucher FP, Harper J: Duration of effusion after antibiotic treatment for acute otitis media: comparison of cefaclor and amoxicillin. Pediatric Infectious Disease Journal 1982, 1: 310–316.

    Google Scholar 

  11. Del Beccaro MA, Mendelman PM, Inglis AF, Richardson MA, Duncan NO, Clausen CR, Stull FL: Bacteriology of acute otitis media: a new perspective. Journal of Pediatrics 1992, 120: 81–84.

    PubMed  Google Scholar 

  12. Bluestone CD, Stephenson JS, Martin LM: Ten-year review of otitis media pathogens. Pediatric Infectious Diseases Journal 1992, 11, Supplement: 7–11.

    Google Scholar 

  13. Coles SJ, Addlestone MB, Kamdar MK, Macklin JL: A comparative study of clarithromycin and amoxicillin suspensions in the treatment of pediatric patients with acute otitis media. Infection 1993, 21 Supplement 4: 272–278.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Second Department of Paediatrics, P & A Kyriakou Children's Hospital, University of Athens, 11527, Athens, Greece

    D. A. Kafetzis, H. Astra & L. Mitropoulos

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  1. D. A. Kafetzis
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  2. H. Astra
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  3. L. Mitropoulos
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Kafetzis, D.A., Astra, H. & Mitropoulos, L. Five-day versus ten-day treatment of acute otitis media with cefprozil. Eur. J. Clin. Microbiol. Infect. Dis. 16, 283–286 (1997). https://doi.org/10.1007/BF01695632

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