Abstract
The effects of glucagon and secretin on food- or morphine-induced motor activity of the distal colon, rectum, and internal anal sphincter were investigated in 12 healthy subjects. Intraluminal pressure changes were measured using a triple-lumen polyvinyl tube assembly with 3 side orifices. Glucagon, administered intravenously, caused significant inhibition of food- or morphine-induced motor activity of both the distal colon and rectum. In contrast, secretin did not suppress morphine-induced motor activity but did significantly inhibit food-stimulated motor activity of the distal colon. The inhibitory effect of secretin on motor activity of the rectum was insignificant. Morphine, but not food, elevated the pressure of the anal sphincter which was not effected by glucagon or secretin. Hyperglycemia, produced by the infusion of 5% glucose, had no effect on motor activity. These studies demonstrate that glucagon but not secretin, in the doses employed, inhibits morphine-induced motor wave activity of both the distal colon and rectum and that this inhibitory effect is not secondary to hyperglycemia. Furthermore, the rise in anal sphincter pressure is not affected by glucagon or secretin.
Similar content being viewed by others
References
Chowdhury AR, Lorber SH: Effects of glucagon and secretin on food- or morphine-induced motor activity of the distal colon, rectum and anal sphincter. Clin Res 23:247A, 1975
Connell AM: Motor actions of the large bowel. Handbook of Physiology, Vol 6, Sect 6: Alimentary Canal. CF Code (ed). Washington, DC, American Physiological Society, 1968
Holdstock DJ, Misiewicz JJ, Smith T, Rowlands EN: Propulsion (mass movement) in the human colon and its relationship to meals and somatic activity. Gut 11:91–99, 1970
Daniel EE: Pharmacology of the gastrointestinal tract. Handbook of Physiology, Alimentary Canal, Vol 4, Sect 6: Alimentary Canal. CF Code (ed). Washington, DC, American Physiological Society, 1968
Bennett A Pharmacology of colonic muscle. Gut 16:307–311, 1975
Schuster MM, Mendeloff AI: Characteristics of rectosigmoid motor function: Their relationship to continence, defecation and disease. Progress in Gastroenterology, Vol 11. GBG Glass (ed). New York, Grune and Stratton, 1970
Dinoso VP Jr, Meshkinpour H, Lorber SH, Gutierrez JG, Chey WY: Motor responses of the sigmoid colon and rectum to exogenous cholecystokinin and secretin. Gastroenterology 65:438–444, 1973
Hogan WJ, Dodds WJ, Hoke SE, Reid DP, Kalkhoff RK, Arndorfer RC: Effect of glucagon on esophageal motor function. Gastroenterology 69:160–165, 1975
Gutierrez JG, Chey WY, Dinoso VP: Actions of cholecystokinin and secretin on the motor activity of the small intestine in man. Gastroenterology 67:35–41, 1974
Cohen S: The action of hormones upon upper gastrointestinal sphincter function. Endocrinology of the Gut. WY Chey and FP Brooks (eds). Thorofare, New Jersey, Charles B. Slack, Inc., 1974
Lorber SH, Shay H: Technical and physiological considerations in measuring gastrointestinal pressures in man. Gastroenterology 27:478–487, 1954
Harris LD, Winans CS, Pope CE II: Determination of yield pressures: A method for measuring anal sphincter competence. Gastroenterology 50:754–760, 1966
Deller DJ, Wangel AW: Intestinal motility in man. Gastroenterology 48:45–47, 1965
Chowdhury AR, Dinoso VP, Lorber SH: Characterization of a hyperactive segment at the rectosigmoid junction. Gastroenterology 71:584–588, 1976
Connell AM: The motility of the pelvic colon. Part II. Paradoxical motility in diarrhea and constipation. Gut 3:342–348, 1962
Bloom AA, LoPrasti P, Farrar JT: Motility of the intact colon. Gastroenterology 51:232–240, 1968
Santeusanio F, Faloona GR, Unger RH: Suppressive effect of secretin upon pancreatic alpha cell function. J Clin Invest 51:1743–1749, 1972
Snedecor GW, Cochran WG: Statistical Methods. Ames, Iowa, Iowa State University Press, 1967
Connell AM: Applied physiology of the colon: Factors relevant to diverticular disease. Clin Gastroenterol 4:23–30, 1975
Misiewicz JJ: Colonic motility. Gut 16:311–314, 1975
Meshkinpour H, Dinoso VP, Lorber SH: Effect of intraduodenal administration of essential amino acids and sodium oleate on motor activity of the sigmoid colon. Gastroenterology 66:373–377, 1974
Holdstock DJ, Misiewicz JJ: Factors controlling colonic motility: Colonic pressures and transit after meals in patients with total gastrectomy, pernicious anemia or duodenal ulcer. Gut 11:100–110, 1970.
Painter NS, Truelove SC: The intraluminal pressure patterns in diverticulosis of the colon. Gut 5:201–213, 1964
Gardner JD, Malloy RG, Hogan WJ: Pentagastrin and glucagon effects on the internal anal sphincter pressure in man. Clin Res 21:826, 1973
Lorber SH, Shay H: Effects of insulin and glucose on gastric motor activity of dogs. Gastroenterology 43:564–574, 1962
Parmley WW, Sonenblick EH: Glucagon: A new agent in cardiac therapy. Am J Cardiol 27:298–303, 1971
Nord HG, Fontanes AL, Williams JF Jr: Treatment of congestive heart failure with glucagon. Ann Intern Med 72:649–654, 1970
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chowdhury, A.R., Lorber, S.H. Effects of glucagon and secretin on food- or morphine-induced motor activity of the distal colon, rectum, and anal sphincter. Digest Dis Sci 22, 775–780 (1977). https://doi.org/10.1007/BF01694507
Issue Date:
DOI: https://doi.org/10.1007/BF01694507