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Isoflurane for prolonged sedation in the intensive care unit; efficacy and safety

Intensive Care Medicine volume 18, pages 415–421 (1992)Cite this article

Abstract

Objective: To compare isoflurane with midazolam for prolonged sedation in ventilated patients.Design: Randomised controlled study.Setting: General intensive care unit in university teaching hospital.Patients: Sixty patients aged 17–80 years who required mechanical ventilation for more than 24h.Interventions: Sedation with either 0.1–0.6% isoflurane in an air-oxygen mixture (30 patients) or a continuous infusion of midazolam 0.02–0.20 mg/kg/h (30 patients). Sedation was assessed initially and hourly thereafter on a six point scale. The trial sedative was stopped when the patient was ready for weaning from ventilatory support.Measurements and results: Measurements were made of haemodynamic, respiratory and biochemical variables regularly during the period of sedation and for a week after stopping the sedative agent. There was no difference in any of the physiological or biochemical variables recorded between the two groups. Patients sedated with isoflurane recovered more rapidly and were weaned from mechanical ventilation sooner than those sedated with midazolam.Conclusions: Isoflurane is a useful agent for prolonged sedation of ventilated patients and does not have any adverse effect on the cardiorespiratory system or on hepatic, renal or adrenal function.

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Author information

Affiliations

  1. Intensive Care Unit, Bristol Royal Infirmary, Upper Maudlin Street, BS2 8HW, Bristol, UK

    E. M. Spencer & S. M. Willatts

  2. Sir Humphry Davy Department of Anaesthesia, Bristol Royal Infirmary, Upper Maudlin Street, BS2 8HW, Bristol, UK

    E. M. Spencer

Authors
  1. E. M. Spencer
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  2. S. M. Willatts
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Additional information

This study was supported by Abbott Laboratories Ltd, Abbott House, Moorbridge Road, Maidenhead SL6 8JG, Berks, UK

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Spencer, E.M., Willatts, S.M. Isoflurane for prolonged sedation in the intensive care unit; efficacy and safety. Intensive Care Med 18, 415–421 (1992). https://doi.org/10.1007/BF01694344

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  • DOI: https://doi.org/10.1007/BF01694344

Key words

  • Anaesthetics
  • Isoflurane
  • Intensive care
  • Sedation