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Inoculum effect and bactericidal activity of cefditoren and other antibiotics againstStreptococcus pneumoniae, Haemophilus influenzae, andNeisseria meningitidis

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Abstract

The inoculum effect on minimum inhibitory and minimum bactericidal concentrations of cefditoren, benzylpenicillin, ampicillin, cefotaxime, ceftriaxone, and meropenem against six clinical isolates each ofStreptococcus pneumoniae, Haemophilus influenzae, andNeisseria meningitidis was studied using inocula of approximately 104 to 105 and 107 to 108 cfu/ml. Vancomycin was also studied againstStreptococcus pneumoniae. The inoculum effect was observed only with benzylpenicillin and ampicillin against five of six strains ofHaemophilus influenzae. All antibiotics tested were bactericidal.

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Authors and Affiliations

  1. Department of Medical Microbiology, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040, Madrid, Spain

    F. Soriano, M. Jiménez, P. García-Corbeira & R. Fernández-Roblas

  2. Department of Research and Development, Tedec-Meiji Farma S.A., Madrid, Spain

    P. Coronel & M. Gimeno

Authors
  1. F. Soriano
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  2. P. Coronel
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  3. M. Gimeno
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  4. M. Jiménez
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  5. P. García-Corbeira
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  6. R. Fernández-Roblas
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Soriano, F., Coronel, P., Gimeno, M. et al. Inoculum effect and bactericidal activity of cefditoren and other antibiotics againstStreptococcus pneumoniae, Haemophilus influenzae, andNeisseria meningitidis . Eur. J. Clin. Microbiol. Infect. Dis. 15, 761–763 (1996). https://doi.org/10.1007/BF01691969

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  • DOI: https://doi.org/10.1007/BF01691969

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